1032759-30-0

Basic information

• Product Name: 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER
• Synonyms: 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER;(2-(DIMETHYLAMINO)PYRIMIDIN-5-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1032759-30-0
• Molecular Formula: C₁₂H₂₀BN₃O₂
• Molecular Weight: 249.1171
• Mol File: 1032759-30-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 107-112℃
• Boiling Point: 369.2±34.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.94±0.10(Predicted)
• CAS DataBase Reference: 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(1032759-30-0)
• EPA Substance Registry System: 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(1032759-30-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1032759-30-0(Hazardous Substances Data)

Usage

General Description

2-Dimethylamino-pyrimidine-5-boronic acid pinacol ester is a chemical compound that is commonly used in organic synthesis. It is a boronic acid ester, which means it contains a boron atom attached to an alkyl group and an alcohol group. 2-DIMETHYLAMINO-PYRIMIDINE-5-BORONIC ACID PINACOL ESTER is known for its ability to react with a wide range of other compounds, making it useful in the production of various pharmaceuticals, agrochemicals, and organic materials. Its unique structure and reactivity make it a valuable tool for chemists and researchers working in the field of organic chemistry.

Upstream product

• 38696-21-8 5-bromo-N,N-dimethylpyrimidin-2-amine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1382995-32-5 1-{5-chloro-3-[2-(dimethylamino)pyrimidin-5-yl]-2-methoxy-4-methylphenyl}ethanone 
• 1332448-14-2 5-(3-(2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)phenyl)-N,N-dimethylpyrimidin-2-amine 
• 1332447-93-4 C₂₅H₂₇N₅ 
• 1310584-20-3 Cu(III) 10-(4-(2-dimethylaminopyrimidin-5-yl)phenyl)-5,15-bis(pentafluorophenyl)corrole 
• 1206194-28-6 N-(4-(5-(2-(dimethylamino)pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)acetamide 
• 1034303-40-6 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide 

Relevant articles and documents

Prospective evaluation and success of a machine learning hit-to-lead drug development program against phosphatidylinositol 3-kinase α

As a result of the rapidly increasing cost of drug development, efficient methods for early identification of compounds with a high probability of clinical success are needed. Herein, we describe a cheminformatics protocol which dramatically increases quality candidate identification and should reduce the attrition rate of compounds entering the clinic, increasing the cost-effectiveness of drug development. Against the oncology target phosphatidylinositol 3-kinase α, all five compounds synthesized from the protocol were found to have low nanomolar activity. We therefore propose that our protocol can be used as a tool for reducing the synthetic burden required for hit-to-lead optimization.

SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS

The present invention relates to LpxC antibacterial compounds of Formula (1A), corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions:, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.

PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY

PROBLEM TO BE SOLVED: To provide phosphoinositide 3-kinase inhibitors with a zinc binding moiety. SOLUTION: There is provided a compound represented by formula (I) in the figure. (X is S, O or the like; Y is CH, N or the like; G1 is optionally substituted N or the like; R1 and R2 are each independently H or the like; C is a substituted heterocycle or the like; B is a linear alkyl or the like; Ra and Rb together with the nitrogen atom coupled to them are morpholino or the like; G2 is an indazole ring or the like; q, r and s are independently from 0 to 1, provided that at least one of them is 1; t is from 0 to 1; n is from 0 to 4; and p is from 0 to 2.) COPYRIGHT: (C)2016,JPOandINPIT