1033464-75-3

Basic information

• Product Name: 2-methyl-2H-benzotriazole-4-sulfonyl chloride
• CAS NO: 1033464-75-3
• Molecular Weight: 231.663
• Mol File: 1033464-75-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-2H-benzotriazole-4-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2H-benzotriazole-4-sulfonyl chloride(1033464-75-3)
• EPA Substance Registry System: 2-methyl-2H-benzotriazole-4-sulfonyl chloride(1033464-75-3)

Safety Data

• Hazardous Substances Data: 1033464-75-3(Hazardous Substances Data)

Upstream product

• 16584-00-2 2-methylbenzotriazole 

Downstream Products

• 1033464-69-5 2-methyl-2H-benzotriazole-5-sulfonic acid [5-bromo-2-(piperidine-1-carbonyl)-phenyl]-amide 
• 1033464-68-4 2-methyl-2H-benzotriazole-4-sulfonic acid [5-bromo-2-(piperidine-1-carbonyl)-phenyl]-amide 

Relevant articles and documents

Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis

A novel series of cholecystokinin-2 receptor (CCK-2R) antagonists has been identified, as exemplified by anthranilic sulfonamide 1 (pKi = 7.6). Pharmacokinetic and stability studies indicated that this series of compounds suffered from metabolic degradation, and that both the benzothiadiazole and piperidine rings were rapidly oxidized by liver enzymes. A combination of synthesis, computational methods, 1H NMR conformational studies, and X-ray crystallographic analyses were applied to elucidate key pharmacophore elements, and to discover analogs with improved pharmacokinetic profiles, and high receptor binding affinity and selectivity.