1034266-12-0

Basic information

• Product Name: C₂₀H₂₇N₃O₃S
• Synonyms: C₂₀H₂₇N₃O₃S
• CAS NO: 1034266-12-0
• Molecular Weight: 389.519
• Mol File: 1034266-12-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₇N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₇N₃O₃S(1034266-12-0)
• EPA Substance Registry System: C₂₀H₂₇N₃O₃S(1034266-12-0)

Safety Data

• Hazardous Substances Data: 1034266-12-0(Hazardous Substances Data)

Upstream product

• 10599-17-4 1-(3-chloropropyl)-4-phenylpiperazine 
• 1129-26-6 4-methoxybenzene sulfonamide 

Relevant articles and documents

Preparation of piperazine derivatives as 5-HT7 receptor antagonists

Twenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] benzene sulfonamides and N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] naphthyl sulfonamides were prepared and evaluated as 5-HT7 receptor antagonists. Most of the compounds showed the IC50 values of 12-580 nM. Four methyl branched analogues were also obtained, but the activity for methyl branched analogues was almost same as its straight chain congeners. Among the synthesized compounds, 3c showed a good activity on 5-HT7 receptors and a good selectivity on 5-HT1a, 5-HT2a, 5-HT2c, and 5-HT6 receptors.