10345-40-1

Basic information

• Product Name: Carbamothioic acid, dimethyl-, O-(4-nitrophenyl) ester
• CAS NO: 10345-40-1
• Molecular Formula: C9H10N2O3S
• Molecular Weight: 226.256
• Mol File: 10345-40-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamothioic acid, dimethyl-, O-(4-nitrophenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamothioic acid, dimethyl-, O-(4-nitrophenyl) ester(10345-40-1)
• EPA Substance Registry System: Carbamothioic acid, dimethyl-, O-(4-nitrophenyl) ester(10345-40-1)

Safety Data

• Hazardous Substances Data: 10345-40-1(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 1132-69-0 4-nitrophenyl chlorothionoformate 
• 124-40-3 dimethyl amine 

Downstream Products

• 1849-36-1 para-nitrobenzenethiol 
• 7305-12-6 S-(p-nitrophenyl) N,N-dimethylthiocarbamate 

Relevant articles and documents

The Newman-Kwart rearrangement: A microwave kinetic study

(Chemical Equation Presented) The kinetic profile of the Newman-Kwart rearrangement has been evaluated using microwave heating. After first demonstrating equivalence between conventional convective heating and microwave heating, data was gathered and anal

Electrochemically Catalyzed Newman-Kwart Rearrangement: Mechanism, Structure-Reactivity Relationship, and Parallels to Photoredox Catalysis

The facilitation of redox-neutral reactions by electrochemical injection of holes and electrons, also known as "electrochemical catalysis", is a little explored approach that has the potential to expand the scope of electrosynthesis immensely. To systematically improve existing protocols and to pave the way toward new developments, a better understanding of the underlying principles is crucial. In this context, we have studied the Newman-Kwart rearrangement of O-arylthiocarbamates to the corresponding S-aryl derivatives, the key step in the synthesis of thiophenols from the corresponding phenols. This transformation is a particularly useful example because the conventional method requires temperatures up to 300 °C, whereas electrochemical catalysis facilitates the reaction at room temperature. A combined experimental-quantum chemical approach revealed several reaction channels and rendered an explanation for the relationship between the structure and reactivity. Furthermore, it is shown how rapid cyclic voltammetry measurements can serve as a tool to predict the feasibility for specific substrates. The study also revealed distinct parallels to photoredox-catalyzed reactions, in which back-electron transfer and chain propagation are competing pathways.

Palladium-catalyzed intramolecular oxidative C-H sulfuration of aryl thiocarbamates

A palladium-catalyzed intramolecular C-H bond sulfuration reaction of aryl thiocarbamates has been developed. This strategy provides a new route to benzo[d][1,3]oxathiol-2-ones with tolerance of a wide range of substituents. Mechanistic studies suggested

A comparison of commercial microwave reactors for scale-up within process chemistry

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.