103756-12-3

Basic information

• Product Name: 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)
• Synonyms: 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)
• CAS NO: 103756-12-3
• Molecular Weight: 295.381
• Mol File: 103756-12-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)(103756-12-3)
• EPA Substance Registry System: 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)(103756-12-3)

Safety Data

• Hazardous Substances Data: 103756-12-3(Hazardous Substances Data)

Upstream product

• 2538-50-3 β-Methylaminoethyl phenyl ketone hydrochloride 
• 768-03-6 Phenyl vinyl ketone 
• 50-00-0 formaldehyd 
• 593-51-1 methylamine hydrochloride 
• 98-86-2 acetophenone 
• 936-59-4 3-chloropropiophenone 
• 27152-62-1 3-(N-methylamino)propiophenone 

Downstream Products

• 768-03-6 Phenyl vinyl ketone 
• 5409-66-5 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 
• 4661-15-8 1-methyl-3-benzoyl-4-hydroxy-4-phenylpiperidine hydrochloride 

Relevant articles and documents

Identification of the anti-mycobacterial functional properties of piperidinol derivatives

Background and Purpose: Tuberculosis (TB) remains a major global health threat and is now the leading cause of death from a single infectious agent worldwide. The current TB drug regimen is inadequate, and new anti-tubercular agents are urgently required to be able to successfully combat the increasing prevalence of drug-resistant TB. The purpose of this study was to investigate a piperidinol compound derivative that is highly active against the Mycobacterium tuberculosis bacillus. Experimental Approach: The antibacterial properties of the piperidinol compound and its corresponding bis-Mannich base analogue were evaluated against M. smegmatis and Gram-negative organisms. Cytotoxicity studies were undertaken in order to determine the selectivity index for these compounds. Spontaneous resistant mutants of M.?smegmatis were generated against the piperidinol and corresponding bis-Mannich base lead derivatives and whole genome sequencing employed to determine the genetic modifications that lead to selection pressure in the presence of these compounds. Key Results: The piperidinol and the bis-Mannich base analogue were found to be selective for mycobacteria and rapidly kill this organism with a cytotoxicity selectivity index for mycobacteria of >30-fold. Whole genome sequencing of M.?smegmatis strains resistant to the lead compounds led to the identification of a number of single nucleotide polymorphisms indicating multiple targets. Conclusion and Implications: Our results indicate that the piperidinol moiety represents an attractive compound class in the pursuit of novel anti-tubercular agents. Linked Articles: This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro-organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc.