10376-59-7Relevant articles and documents
Synthesis of quinazoin-4-ones through an acid ion exchange resin mediated cascade reaction
He, Lei,Li, Wanmei,Xu, Jun,Yang, Huiyong,Zhang, Pengfei,Zhang, Yilan
, p. 4406 - 4414 (2020/10/20)
An interesting cascade reaction of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide in the presence of an acid ion exchange resin is described. In this reaction, a range of substrates bearing various substituent groups are well compatible. This work provides a green and atom-economical alternative approach for the synthesis of quinazolin-4-ones in good yields.
Investigating biological activity spectrum for novel styrylquinazoline analogues
Jampilek, Josef,Musiol, Robert,Finster, Jacek,Pesko, Matus,Carroll, James,Kralova, Katarina,Vejsova, Marcela,O'Mahony, Jim,Coffey, Aidan,Dohnal, Jiri,Polanski, Jaroslaw
scheme or table, p. 4246 - 4265 (2010/03/01)
In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds.
TREATMENT OF PLATELET DERIVED GROWTH FACTOR RELATED DISORDERS SUCH AS CANCERS
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