103878-58-6

Basic information

• Product Name: 5-Bromothiazole-4-carboxylic acid
• Synonyms: 5-BROMOTHIAZOLE-4-CARBOXYLIC ACID;5-Bromo-1,3-thiazole-4-carboxylic acid;4-Thiazolecarboxylicacid,5-bromo-(9CI);5-BROMOTHIAZOLE-4-CARBOXYLIC ACID, 95+%;5-Bromo-4-carboxy-1,3-thiazole;5-broMo-thiazol-4-carboxylic acid;4-Thiazolecarboxylic acid, 5-broMo-
• CAS NO: 103878-58-6
• Molecular Formula: C4H2BrNO2S
• Molecular Weight: 208.03
• Product Categories: THIAZOLE;blocks;Bromides;Carboxes;Thiazoles
• Mol File: 103878-58-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.673 °C at 760 mmHg
• Flash Point: 176.163 °C
• Appearance: /
• Density: 2.063 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.17±0.10(Predicted)
• CAS DataBase Reference: 5-Bromothiazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromothiazole-4-carboxylic acid(103878-58-6)
• EPA Substance Registry System: 5-Bromothiazole-4-carboxylic acid(103878-58-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 103878-58-6(Hazardous Substances Data)

Usage

General Description

5-Bromothiazole-4-carboxylic acid is a chemical compound with the molecular formula C5H3BrN2O2S. It is a heterocyclic compound that contains a thiazole ring and a carboxylic acid group. 5-Bromothiazole-4-carboxylic acid is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical and biologically active compounds. It has been studied for its potential applications in the development of new drugs for the treatment of cancer, inflammation, and other diseases. 5-Bromothiazole-4-carboxylic acid has also been investigated for its antifungal and antibacterial properties, making it a versatile and valuable chemical in medicinal chemistry research.

InChI:InChI=1/C4H2BrNO2S/c5-3-2(4(7)8)6-1-9-3/h1H,(H,7,8)

Upstream product

• 913836-22-3 5-bromothiazole-4-carboxylic acid methyl ester 
• 61830-23-7 ethyl 5‐bromo‐1,3‐thiazole‐4‐carboxylate 
• 61830-21-5 2-amino-5-bromthiazol-4-carbonic acid ethyl ester 

Downstream Products

• 913836-22-3 5-bromothiazole-4-carboxylic acid methyl ester 
• 1025468-10-3 5‐bromo‐1,3‐thiazole‐4‐carboxamide 
• 1423703-73-4 C₁₂H₁₁BrN₂O₂S 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

ANTIBACTERIAL COMPOUNDS AND NEW USES THEREOF

This invention relates to a series of compounds of formula (I) for use in treating infections caused by obligate anaerobic bacteria, including Clostridium difficile, and to methods of treating said infections by administering said compounds. The compounds can be used against strains of obligate anaerobic bacteria that have developed resistance to other antibiotics. Many compounds used in the invention contain a tricyclic ring system.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.