103986-53-4Relevant articles and documents
Perylenophthalocyanines
Cammidge, Andrew N.,Gopee, Hemant
, p. 8609 - 8613 (2006)
The first perylenophthalocyanines have been synthesised using a Diels-Alder reaction between dialkylperylenes and fumaronitrile as the key step towards the dinitrile precursors. As expected the octaalkylperylenophthalocyanines show red-shifted absorption spectra. They are high melting solids that do not display mesophase behaviour at accessible temperatures. A 3:1 phthalocyanine/ perylenophthalocyanine hybrid material, prepared by a mixed macrocyclisation reaction, presents an unusual board-like molecular profile. Its absorption maxima lie between those observed for the parent phthalocyanines and the symmetrical perylenophthalocyanines. The spectrum shows a characteristic split Q-band due to the reduced symmetry of the core. This material is non-mesogenic but is sufficiently soluble to permit processing and characterisation. The 1H NMR spectrum indicates that at least two of the appended alkyl chains are displaced out of the macrocycle plane and lie in its shielding region - an arrangement that disfavours the face-to-face packing required for mesophase formation.
Thiophene derivatives used as inhibitor of URAT1
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Paragraph 0142; 0144; 0145; 0146, (2019/04/26)
The invention relates to thiophene derivatives used as an inhibitor of urate transporter 1 (URAT1), in particular relates to the thiophene derivatives represented by a general formula (I) shown in thedescription, a pharmaceutically-acceptable salt of the thiophene derivatives, and preparation methods of the thiophene derivatives and the pharmaceutically-acceptable salt, and particularly relates to an application of the thiophene derivatives and the pharmaceutically-acceptable salt used as a therapeutic agent for a disease associated with an abnormal uric acid level.
ROCK inhibitor containing methylnaphthalene and propylene glycol thiophene amide
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Paragraph 0042; 0045; 0046, (2018/05/16)
The invention belongs to the technical field of medicine. In particular, the invention relates to a compound containing a methylnaphthalene and propylene glycol thiophene amide structure and capable of serving as a ROCK inhibitor, a preparation method thereof and application thereof to preparation of medicines for treating sexual dysfunction, inflammatory diseases, ophthalmic diseases, respiratorysystem diseases and the like. (The formula is as shown in the description).
ROCK inhibitor containing methylnaphthalene and nitrile thiophene amide structures and application
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Paragraph 0042; 0045; 0046, (2018/07/30)
The invention belongs to the technical field of medicine, in particular to a compound containing methylnaphthalene and nitrile thiophene amide structure, which can serve as a ROCK inhibitor, a preparation method thereof, and application thereof to preparation of medicine for treating sexual dysfunction, inflammatory diseases, ophthalmic diseases and respiratory system diseases.