104-11-0

Basic information

• Product Name: (4-CHLORO-BENZYL)-METHYL-AMINE
• Synonyms: (4-Chloro-benzyl)-methyl-amine ,97%;4-Chloro-N-methylbenzylamine;4-Chloro-N-methylbenzenemethanamine;N-Methyl-4-chlorobenzylamine;Description: N-(4-chlorobenzyl)-N-methylamine;(4-CHLORO-BENZYL)-ME;(4-Chlorophenyl)-N-methylmethylamine;1-(4-chlorophenyl)-N-MethylMethanaMine
• CAS NO: 104-11-0
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• EINECS: 203-175-3
• Product Categories: amine|alkyl chloride;Amines and Anilines;Halides;Polyamines
• Mol File: 104-11-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 77 °C
• Flash Point: 78.9 ºC
• Appearance: /
• Density: 1.088 g/cm³
• Vapor Pressure: 0.232mmHg at 25°C
• Refractive Index: 1.5380 to 1.5420
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.50±0.10(Predicted)
• CAS DataBase Reference: (4-CHLORO-BENZYL)-METHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-BENZYL)-METHYL-AMINE(104-11-0)
• EPA Substance Registry System: (4-CHLORO-BENZYL)-METHYL-AMINE(104-11-0)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 22-34-52-41-37/38
• Safety Statements: 23-26-36/37/39-45-39
• RIDADR: 2735
• TSCA: Yes
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 104-11-0(Hazardous Substances Data)

Usage

General Description

(4-CHLORO-BENZYL)-METHYL-AMINE is a chemical compound with the molecular formula C8H9ClN. It is a substituted benzylamine, which is a type of organic compound that contains a benzene ring with an amino group attached to the benzyl carbon. The presence of a chloro group in the benzyl portion of the molecule gives (4-CHLORO-BENZYL)-METHYL-AMINE its specific chemical properties. (4-CHLORO-BENZYL)-METHYL-AMINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle (4-CHLORO-BENZYL)-METHYL-AMINE with care, as it can be hazardous if not used properly.

InChI:InChI=1/C8H10ClN/c1-10-6-7-2-4-8(9)5-3-7/h2-5,10H,6H2,1H3/p+1

Upstream product

• 622-95-7 4-chlorobenzyl bromide 
• 67-56-1 methanol 
• 27032-10-6 4-chlorobenzyl azide 
• 104-88-1 4-chlorobenzaldehyde 
• 74-89-5 methylamine 
• 15184-98-2 N,N-dimethyl-4-chlorobenzylamine 
• 13114-22-2 N-(4-chlorobenzylidene)methylamine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 15481-45-5 methyl p-chlorobenzenesulphonate 
• 104-86-9 4-chlorobenzylamine 
• 6214-20-6 methyl 4-nitrobenzenesulfonate 
• 593-51-1 methylamine hydrochloride 
• 80-18-2 Methyl benzenesulfonate 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 1003887-45-3 (R)-tert-butyl 2-[(4-chlorobenzyl)(methyl)carbamoyl]pyrrolidine-1-carboxylate 
• 143426-16-8 2--5-chlorobenzaldehyde 
• 25251-57-4 p-chlorobenzyltrimethylammonium bromide 
• 622-95-7 4-chlorobenzyl bromide 
• 1131740-36-7 N-(4-chloro-benzyl)-2-(4-fluoro-phenyl)-N-methyl-acetamide 
• 6873-44-5 p-chloro-N-methylbenzamide 
• 104936-73-4 N-methyl-N-[(4-chlorophenyl)methyl]formamide 

Relevant articles and documents

Efficient Approaches for the Synthesis of Diverse α-Diazo Amides

Metal-catalysed carbenoid chemistry can be exploited for the synthesis of diverse ranges of small molecules from α-diazo carbonyl compounds. In this paper, three synthetic approaches to α-diazo amides are described, and their scope and limitations are determined. On the basis of these synthetic studies, recommendations are provided to assist the selection of the most appropriate approach for specific classes of product. The availability of practical and efficient syntheses of diverse α-diazo acetamides is expected to facilitate the discovery of many different classes of bioactive small molecules.

Epoxide-Mediated Stevens Rearrangements of α-Amino-Acid-Derived Tertiary Allylic, Propargylic, and Benzylic Amines: Convenient Access to Polysubstituted Morpholin-2-ones

A new strategy has been established for the synthesis of polysubstituted morpholin-2-ones through Stevens rearrangements of tertiary amines via in situ activation with epoxides. A range of α-amino acid-derived tertiary allylic, propargylic, and benzylic amines reacted with epoxides in the presence of zinc halide catalysts to afford structurally diverse allyl-, allenyl-, and benzyl-substituted morpholin-2-ones, respectively, in moderate-to-good yields with high regioselectivity. The process involves [2,3]- and [1,2]-Stevens rearrangements of quaternary ammonium ylide intermediates and constitutes a very convenient method to prepare polysubstituted morpholin-2-ones through tandem formation of C?N, C?O, and C?C bonds. Moreover, replacing epoxides with aziridines permitted the synthesis of polysubstituted piperazin-2-ones.

Tandem C(sp3)?H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones

Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of isoindolinones with aryl bromides (22 examples) using a palladium(II) acetate/NIXANTPHOS-based catalyst system. Additionally 3-aryl-3-hydroxyisoindolinone derivatives, which exhibit anti-tumor activity, can be accessed via a tandem reaction. Thus, when the arylation product is exposed to air under basic conditions, in situ oxidation takes place to install the 3-hydroxy group. Furthermore, a tandem arylation/allylic substitution reaction is advanced in which both the arylation and allylic substitution are catalyzed by the same palladium catalyst. Finally, a tandem arylation/alkylation procedure is presented. These tandem reactions enable the synthesis of a variety of structurally diverse isoindolinone derivatives from common starting materials. (Figure presented.).