104-16-5Relevant articles and documents
Thiourea and thiosemicarbazide derivatives: Structure, transformations, and pharmacological activity. Hepatoprotective effect of triazino- and imidazoindoles
Tomchin,Okovityi,Velezheva,Smirnov
, p. 362 - 369 (1998)
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Synthesis and trazodone-like pharmacological profile of 1- and 2--propyl>benzotriazoles
Caliendo, G.,Carlo, R. Di,Meli, R.,Perissutti, E.,Santagada, V.,et al.
, p. 969 - 974 (1993)
A series of 1- and 2--propyl>benzotriazoles were prepared and evaluated for their trazodone-like pharmacological profile; as preliminary pharmacological screening, the compounds were tested for their antiserotonergic, antiadrenergic and antihistaminic in vitro activity as well as for their analgesic in vivo action.Structure-activity relationships showed that among the synthesized compounds, the analogues bearing on the 4-piperazine nitrogen either an unsubstituted phenyl ring or a 2- or 3-chloro phenyl moiety show a pharmacological profilesimilar to that of the antidepressant trazodone. benzotriazoles / antiserotonergic / antiadrenergic / antihistaminic/ analgesic
Zinc mediated alkylation of cyclic secondary amines
Murty,Jyothirmai,Krishna, Palakodety Radha,Yadav
, p. 2483 - 2486 (2003)
Zinc metal mediated simple and efficient alkylation of cyclic secondary amines e.g., piperazines and morpholine with allyl bromide, chlorobromo propane and p-methoxy benzyl bromide is described in good yields.
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF
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Paragraph 0537; 0538; 0539, (2015/11/30)
A compound represented by Formula [1] (in the formula, Z1 represents N, CH, or the like; X1 represents NH or the like; R1 represents a heteroaryl group or the like; each of R2, R3, and R4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R5 represents a heteroaryl group or the like) or salt thereof.