1040101-01-6

Basic information

• Product Name: 1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMO-
• Synonyms: 1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMO-;3-Bromo-1H-indazole-7-carboxylic acid;3-bromo-2H-indazole-7-carboxylic acid
• CAS NO: 1040101-01-6
• Molecular Formula: C8H5BrN2O2
• Molecular Weight: 241.0415
• Mol File: 1040101-01-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 493.4 °C at 760 mmHg
• Flash Point: 252.2 °C
• Appearance: /
• Density: 1.946 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.31±0.10(Predicted)
• CAS DataBase Reference: 1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMO-(1040101-01-6)
• EPA Substance Registry System: 1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMO-(1040101-01-6)

Safety Data

• Hazardous Substances Data: 1040101-01-6(Hazardous Substances Data)

Usage

General Description

1H-Indazole-7-carboxylic acid, 3-bromo- is a chemical compound with the molecular formula C9H6BrN3O2. It is a derivative of indazole, a heterocyclic aromatic organic compound. This chemical has potential pharmaceutical and medicinal applications due to its involvement in the synthesis of various organic compounds and pharmaceutical intermediates. Its bromine substituent makes it a valuable building block for the synthesis of biologically active molecules and pharmaceuticals. Additionally, it has been studied for its potential anti-inflammatory and anti-cancer properties, making it a versatile compound for drug discovery and development.

Upstream product

• 945762-00-5 3-bromo-7-cyano-1H-indazole 

Relevant articles and documents

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.