104131-70-6

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1,2-dimethyl-, methyl ester, (1R,2R)-rel- (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 1,2-dimethyl-, methyl ester, (1R,2R)-rel- (9CI)
• CAS NO: 104131-70-6
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• Product Categories: ACIDHALIDE
• Mol File: 104131-70-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1,2-dimethyl-, methyl ester, (1R,2R)-rel- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1,2-dimethyl-, methyl ester, (1R,2R)-rel- (9CI)(104131-70-6)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1,2-dimethyl-, methyl ester, (1R,2R)-rel- (9CI)(104131-70-6)

Safety Data

• Hazardous Substances Data: 104131-70-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 80-59-1 Tiglic acid 

Relevant articles and documents

Stereoselectivity and Generality of the Palladium-Catalysed Cyclopropanation of α,β-Unsaturated Carboxylic Acids Derivatized with Oppolzer's Sultam

A series of α,β-unsaturated carboxylic acids derivatized with camphorsultam 1 a s a chiral auxiliary has been stereoselectively cyclopropanated. the selectivity of the reaction produces cyclopropanated products with the 1R,2R absolute configuration as indicated by the optical rotations as well as by an X-ray structure determineation.The temperature dependence of the reaction was studied with three substrates. the highest stereoselectivity was obtained at temperatures above 25 deg C.Branching at the α- or β-carbons disfavours complete conversion, and electron-withdrawing substituents at these positions seem to prevent the reaction.The auxiliary was removed by using titanium(IV) isopropoxide in benzyl alcohol followed by alkaline hydrolysis of the intermediate ester. the potent 5-HT1A receptor agonist (1R,2S)-2-(2-hydroxyphenyl)-N,N-dipropylcyclopropylamine 13 was synthesized by this method