1041439-31-9Relevant articles and documents
Practical synthesis of a renin inhibitor via a diastereoselective dieckmann cyclization
Gauvreau, Danny,Hughes, Greg J.,Lau, Stephen Y. W.,McKay, Daniel J.,O'Shea, Paul D.,Sidler, Rick R.,Yu, Bing,Davies, Ian W.
supporting information; experimental part, p. 5146 - 5149 (2011/02/23)
A scalable synthesis of a potent renin inhibitor (1) is described. The absolute stereochemistry is set via an unprecedented diastereoselective Dieckmann cyclization directed by a remote chiral protecting group. This transformation enables preparation of chiral 1,3-[3.3.1]-diazabicyclononenes by desymmetrization of alkyl-esters, with selectivities ranging from 4 to 17:1.