1041849-95-9

Basic information

• Product Name: 1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol
• CAS NO: 1041849-95-9
• Molecular Weight: 238.789
• Mol File: 1041849-95-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol(1041849-95-9)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol(1041849-95-9)

Safety Data

• Hazardous Substances Data: 1041849-95-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1239497-03-0 4-(4-chlorobenzyl)-2-propylthiazole 
• 1239497-06-3 5-(4-chlorophenyl)-2-propyl-4-((trimethylsilyl)methyl)thiazole 
• 1252883-24-1 (3-(4-chlorophenyl)-5-phenylpenta-1,4-diynyl)trimethylsilane 
• 7342-10-1 1-(4-chlorophenyl)prop-2-yn-1-yl acetate 
• 29805-11-6 1-(4-chlorophenyl)prop-2-yn-1-ol 
• 56955-39-6 1-(4-chlorophenyl)-2-oxopropyl acetate 
• 1297409-37-0 1-(4-chlorophenyl)-2-(5-(4-chlorophenyl)furan-2-yl)ethanone 
• 1297409-02-9 1,6-bis(4-chlorophenyl)hexa-2,4-diyne-1,6-diol 
• 1313403-72-3 3-(1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-ynyl)-4-hydroxy-2H-chromen-2-one 
• 1313403-44-9 2-(1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-ynyl)-1,3-diphenylpropane-1,3-dione 
• 1352742-20-1 (R)-1-(4-chlorophenyl)-3-(trimethylsilyl)prop-2-ynyl acetate 
• 1361959-87-6 1-(3-(4-chlorophenyl)propa-1,2-dienyl)-2,4-dimethylbenzene 
• 1361959-88-7 2-(3-(4-chlorophenyl)propa-1,2-dienyl)-1,3-dimethylbenzene 
• 1361960-18-0 C₁₇H₁₅Cl 

Relevant articles and documents

Redox-Neutral Arylations of Vinyl Cation Intermediates

Herein we present a new unified concept for C?C bond formation under redox-neutral conditions. Our strategy hinges upon interception of a vinyl cation with a sulfoxide resulting in simultaneous C–C and C?O bond formation and arylation. A range of structurally diverse vinyl cations are generated in situ in the presence of a sulfoxide, resulting in hydrative arylation, direct arylation of enol triflates and interrupted Meyer–Schuster rearrangement. Mechanistic investigations showcase the crucial role played by the fleeting vinyl cation intermediate and structural features that lead to its stabilization. Applications of the reaction products to synthesis are also presented. (Figure presented.).

Propargylation of CoQ0 through the Redox Chain Reaction

An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect of Sc(OTf)3 and Hantzsch ester. It is suggested to work through the redox chain reaction, which involves hydroquinone and dimeric propargylic moiety intermediates. A broad range of propargylic alcohols can be converted into the appropriate derivatives of CoQ0 containing triple bonds in good to excellent yields. The mechanism of the given transformation is also discussed.

Benzodiazepines HDM2 inhibitor as well as preparation method and application thereof

The invention relates to a benzodiazepines compound, a preparation method of the benzodiazepines compound and medical application of the benzodiazepines compound, in particular to application of the benzodiazepines compound as a HDM2 inhibitor in treatmen