104201-65-2

Basic information

• Product Name: 2-Propenoic acid, 3-(2-fluorophenyl)-, Methyl ester, (E)-
• Synonyms: Methyl (2E)-3-(2-fluorophenyl)prop-2-enoate;2-Propenoic acid, 3-(2-fluorophenyl)-, Methyl ester, (E)-;2-Propenoic acid, 3-(2-fluorophenyl)-, methyl ester, (2E)-
• CAS NO: 104201-65-2
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.1756632
• Mol File: 104201-65-2.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, 3-(2-fluorophenyl)-, Methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(2-fluorophenyl)-, Methyl ester, (E)-(104201-65-2)
• EPA Substance Registry System: 2-Propenoic acid, 3-(2-fluorophenyl)-, Methyl ester, (E)-(104201-65-2)

Safety Data

• Hazardous Substances Data: 104201-65-2(Hazardous Substances Data)

Usage

Role

Chemical Intermediate

Usage

Manufacturing of polymers, resins, and coatings

Toxicity Level

Moderate

Effects

Irritation to skin, eyes, and respiratory system

Handling Precautions

Should be handled and used with caution

Safety Protocols

Must be used in accordance with proper safety protocols

This compound serves as a crucial intermediate in various chemical synthesis processes, particularly in the production of polymers, resins, and coatings. However, its moderate toxicity necessitates careful handling to avoid skin, eye, and respiratory irritation, emphasizing the importance of adhering to safety protocols during its use.

Upstream product

• 67-56-1 methanol 
• 18944-77-9 2-fluorocinnamic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 292638-85-8 acrylic acid methyl ester 
• 79-20-9 acetic acid methyl ester 
• 16695-14-0 Malonic acid monomethyl ester 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 201230-82-2 carbon monoxide 
• 766-49-4 (2-fluorophenyl)acetylene 
• 1993-03-9 o-fluorophenylboronic acid 
• 1072-85-1 o-fluorobromobenzene 
• 348-52-7 1-Fluoro-2-iodobenzene 

Downstream Products

• 76727-24-7 3-(2-fluorophenyl)propan-1-ol 
• 129254-75-7 1-bromo-3-(2-fluorophenyl)-propane 
• 455267-55-7 methyl 2-(2-fluorophenyl)cyclopropanecarboxylate 
• 807369-87-5 (E)-3-(2-fluorophenyl)-prop-2-en-1-ol 
• 104201-75-4 2-(2-Fluoro-phenyl)-4-oxo-cyclopentane-1,1-dicarboxylic acid 

Relevant articles and documents

Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis

Direct α-functionalization of NH2-free glycinates with relatively weak electrophiles such as α,β-unsaturated esters still remains a big challenge in organic synthesis. With chiral pyridoxal 5 d as a carbonyl catalyst, direct asymmetric conjugated addition at the α-C of glycinate 1 a with α,β-unsaturated esters 2 has been successfully realized, to produce various chiral pyroglutamic acid esters 4 in 14–96 % yields with 81–97 % ee's after in situ lactamization. The trans and cis diastereomers can be obtained at the same time by chromatography and both of them can be easily converted into chiral 4-substituted pyrrolidin-2-ones such as Alzheimer's drug Rolipram (11) with the same absolute configuration via tert-butyl group removal and subsequent Barton decarboxylation.

Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6

The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.