1043922-58-2Relevant articles and documents
Azadipeptide nitriles: Highly potent and proteolytically stable inhibitors of papain-like cysteine proteases
Loeser, Reik,Frizler, Maxim,Schilling, Klaus,Guetschow, Michael
supporting information; experimental part, p. 4331 - 4334 (2009/02/08)
(Chemical Presented) Nitrogen instead of carbon: Azadipeptide nitriles resulting from CH/N exchange in the P1 position (see picture) are hitherto unknown. To access these compounds by conversion of amino acid-derived hydrazides with cyanogen bromide both nitrogen atoms of the hydrazide must be substituted. Despite a methylated P2-P1 peptide bond, the azadipeptide nitriles show a strong inhibitory activity against cysteine proteases, and a high stability towards chymotryptic hydrolysis.