1044256-94-1

Basic information

• Product Name: 1-(bromomethyl)-3-chloro-2-methoxybenzene
• Synonyms: 1-(bromomethyl)-3-chloro-2-methoxybenzene
• CAS NO: 1044256-94-1
• Molecular Weight: 235.508
• Mol File: 1044256-94-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(bromomethyl)-3-chloro-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-3-chloro-2-methoxybenzene(1044256-94-1)
• EPA Substance Registry System: 1-(bromomethyl)-3-chloro-2-methoxybenzene(1044256-94-1)

Safety Data

• Hazardous Substances Data: 1044256-94-1(Hazardous Substances Data)

Usage

Description

1-(bromomethyl)-3-chloro-2-methoxybenzene, with the molecular formula C8H8BrClO, is a benzene derivative featuring a bromomethyl group, a chlorine atom, and a methoxy group attached to the benzene ring. 1-(bromomethyl)-3-chloro-2-methoxybenzene is known for its versatility in chemical synthesis and its potential applications across various industries due to the presence of both electron-withdrawing and electron-donating substituents on the benzene ring.

Uses

Used in Pharmaceutical Synthesis:
1-(bromomethyl)-3-chloro-2-methoxybenzene is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with different therapeutic properties, making it a valuable component in the pharmaceutical industry.
Used in Agrochemical Production:
In the agrochemical industry, 1-(bromomethyl)-3-chloro-2-methoxybenzene is utilized as a starting material for the preparation of various agrochemicals. Its chemical structure contributes to the creation of compounds that can be used in the development of pesticides, herbicides, and other agricultural products to enhance crop protection and yield.
Used in Organic Chemistry:
1-(bromomethyl)-3-chloro-2-methoxybenzene also serves as a versatile building block in organic chemistry. It can be used to prepare other organic compounds with diverse properties and applications, making it an essential component in the synthesis of specialty chemicals and materials.

Upstream product

• 87-64-9 2-chloro-6-methylphenol 
• 869088-29-9 (3-chloro-2-methoxyphenyl)methanol 
• 92992-36-4 methyl 3-chloro-2-methoxybenzoate 
• 3260-93-3 3-chloro-2-methoxybenzoic acid 
• 3438-15-1 3-chloro-2-methoxy-1-methylbenzene 

Downstream Products

• 825654-87-3 2-(3-chloro-2-methoxyphenyl)acetonitrile 
• 1379325-95-7 2-(3-chloro-2-methoxyphenyl)ethanamine 

Relevant articles and documents

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS

The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.