1044664-24-5

Basic information

• Product Name: 3-O-Acetyl Ezetimibe
• Synonyms: 3-O-Acetyl Ezetimibe;(3R,4S)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-2-azetidinone;Ezetimibe 3-O-Acetyl Impurity;(3S,4R)-rel-3-[(3R)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-2-azetidinone
• CAS NO: 1044664-24-5
• Molecular Formula: C26H23F2NO4
• Molecular Weight: 451.4619264
• Product Categories: Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1044664-24-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 643.414 °C at 760 mmHg
• Flash Point: 342.924 °C
• Appearance: /
• Density: 1.306 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, DMSO, Methanol
• CAS DataBase Reference: 3-O-Acetyl Ezetimibe(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-Acetyl Ezetimibe(1044664-24-5)
• EPA Substance Registry System: 3-O-Acetyl Ezetimibe(1044664-24-5)

Safety Data

• Hazardous Substances Data: 1044664-24-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

A derivative of 2-azetidinone with antihyperlipoproteinemic properties.

Upstream product

• 163380-20-9 4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone 

Relevant articles and documents

An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).