104468-87-3Relevant articles and documents
Interactive SAR studies: Rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists
Bettinetti, Laura,Schlotter, Karin,Hübner, Harald,Gmeiner, Peter
, p. 4594 - 4597 (2002)
Starting from dopamine receptor ligand BP897, an interactive drug discovery process leading to heterocyclic bioisosteres is demonstrated. The four step strategy involved a careful optimization of geometric and electronic properties by systematic modificat
NITROGENATED HETEROCYCLIC COMPOUND
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Paragraph 1023, (2015/03/28)
The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.
AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES
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, (2013/09/12)
The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.