1045020-74-3

Basic information

• Product Name: 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt
• Synonyms: 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt;4-Methylumbelliferyl alpha-L-idopranosiduronic acid 2-sulphate sodium salt;4-Methylumbelliferyl a-L-idopyranosiduronic acid 2-sulphate disodium salt;4-Methylumbelliferyl α-L-idopyranosiduronic acid 2-sulphate disodium salt
• CAS NO: 1045020-74-3
• Molecular Formula: C16H15O12S.Na
• Molecular Weight: 456.35
• EINECS: 1533716-785-6
• Mol File: 1045020-74-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt(1045020-74-3)
• EPA Substance Registry System: 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt(1045020-74-3)

Safety Data

• Hazardous Substances Data: 1045020-74-3(Hazardous Substances Data)

Usage

Description

4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt is a synthetic compound that serves as a fluorogenic substrate, used primarily in the biochemical analysis and diagnostic assays of specific enzymes.
Used in Diagnostic Applications:
4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt is used as a fluorogenic substrate for the assay of α-L-Iduronidase, an enzyme involved in the lysosomal degradation of glycosaminoglycans. This assay is crucial for the diagnosis of MPS II (Hunter disease), a rare genetic disorder characterized by the deficiency of this enzyme, leading to the accumulation of undegraded glycosaminoglycans in the body.
Used in Research Applications:
In the field of biochemical research, 4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt is used as a tool to study the activity and function of α-L-Iduronidase enzyme. This helps researchers understand the underlying mechanisms of enzymatic processes and contributes to the development of potential therapeutic strategies for related diseases.
Used in Pharmaceutical Development:
4-Methylumbelliferyl α-L-idopranosiduronic acid 2-sulphate sodium salt may also be utilized in the development of pharmaceuticals targeting the treatment of lysosomal storage disorders, such as MPS II. By monitoring the activity of α-L-Iduronidase using this substrate, researchers can evaluate the efficacy of potential drug candidates and optimize their therapeutic properties.