1047953-91-2

Basic information

• Product Name: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT
• Synonyms: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT;TELOMERASE INHIBITOR II, SODIUM SALT;MI-2;MI 2 (MALT1 inhibitor);2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-Acetamide;ATP-dependent helicase CHD4;CHD-4;Mi-2 autoantigen 218 kDa protein
• CAS NO: 1047953-91-2
• Molecular Formula: C₁₉H₁₇Cl₃N₄O₃
• Molecular Weight: 455.72228
• Product Categories: Inhibitors
• Mol File: 1047953-91-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT(1047953-91-2)
• EPA Substance Registry System: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT(1047953-91-2)

Safety Data

• Hazardous Substances Data: 1047953-91-2(Hazardous Substances Data)

Usage

Description

5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT is a synthetic oligonucleotide sequence that functions as a MALT1 inhibitor. It is designed to bind directly to the MALT1 protein, an essential component of the NF-κB signaling pathway, and irreversibly suppress its protease function. This leads to a decrease in NF-κB activity induced by MALT1, ultimately inhibiting cell proliferation and MALT1-mediated cleavage activity.

Uses

Used in Pharmaceutical Industry:
5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT is used as a MALT1 inhibitor for the development of novel therapeutic agents targeting the NF-κB signaling pathway. By inhibiting MALT1-mediated cleavage activity, this compound has the potential to treat various inflammatory and autoimmune diseases, as well as cancer, where the NF-κB pathway is often dysregulated.
Used in Research Applications:
5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT is used as a research tool for studying the role of MALT1 and the NF-κB signaling pathway in various cellular processes. It can be employed in in vitro and in vivo experiments to investigate the effects of MALT1 inhibition on cell proliferation, inflammation, and immune responses, providing valuable insights into the development of new therapeutic strategies.

Upstream product

• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 6954-85-4 3,4-dichlorobenzoyl isothiocyanate 
• 79-11-8 chloroacetic acid 
• 51-44-5 3,4-dichlorbenzoic acid 

Relevant articles and documents

Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors

Recent studies revealed that MALT1 is a promising therapeutic target for the treatment of ABC-DLBCL. Among several reported MALT1 inhibitors, MI-2 as an irreversible inhibitor represents a new class of ABC-DLBCL therapeutics. Due to its inherent potential cross-reactivity, further structure–activity relationship (SAR) study is imperative. In this work, five focused compound libraries based on the chemical structure of MI-2 are designed and synthesized. The systematic SARs revealed that the side chain of 2-methoxyethoxy has little impact on the activity and can be replaced by other functionalized groups, providing new MI-2 analogues with retained or enhanced potency. Compounds 81–83 with terminal hydroxyl group as side chain displayed enhanced activities against MALT1. Replacement of triazole core with pyrazole is also tolerant, while structural modifications on other sites are detrimental. These findings will facilitate further development of small-molecule MALT1 inhibitors.