104831-79-0

Basic information

• Product Name: 1H-Indole-3-carboxaldehyde, 5-methoxy-1-(phenylmethyl)-
• CAS NO: 104831-79-0
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol File: 104831-79-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-carboxaldehyde, 5-methoxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carboxaldehyde, 5-methoxy-1-(phenylmethyl)-(104831-79-0)
• EPA Substance Registry System: 1H-Indole-3-carboxaldehyde, 5-methoxy-1-(phenylmethyl)-(104831-79-0)

Safety Data

• Hazardous Substances Data: 104831-79-0(Hazardous Substances Data)

Upstream product

• 1006-94-6 5-methoxylindole 
• 10601-19-1 5-methoxyindole-3-carboxaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 2975-46-4 3-(trimethylsilyl)prop-2-yn-1-al 
• 1356584-93-4 1-benzyl-5-methoxy-3-vinyl-1H-indole 
• 1574402-27-9 3-(1-benzyl-5-methoxy-1H-indol-3-ylmethylene)-1,3-dihydroindol-2-one 
• 1574402-26-8 3-(1-benzyl-5-methoxy-1H-indol-3-ylmethylene)-1-(2,6-dichlorophenyl)-1,3-dihydroindol-2-one 
• 1574402-25-7 4-(1-benzyl-5-methoxy-1H-indol-3-ylmethylene)-2-(3-chlorophenyl)-5-methyl-2,4-dihydropyrazol-3-one 
• 1356584-57-0 C₁₉H₂₁NO₂ 
• 1356584-66-1 (2S,3S)-methyl 2-(4-methoxybenzamido)-3-(1-benzyl-5-methoxy-1H-indol-3-yl)-2-phenylbutanoate 
• 1207733-71-8 C₂₁H₂₀N₄O₂ 
• 130360-84-8 Methyl (R)-α-(1-phenylmethyl-5-methoxy-3-indolylmethyl) amino-phenylacetate 
• 130360-82-6 Methyl (+/-)-α-(1-phenylmethyl-5-methoxy-3-indolylmethyl) amino-(3-trifluoromethylphenyl)acetate 

Relevant articles and documents

Catalytic Enantioselective Diels-Alder Reactions of Benzoquinones and Vinylindoles with Chiral Magnesium Phosphate Complexes

Tetrahydrocarbazole and its derivatives have received much attention due to the prevalence of this scaffold in natural products and their use in organic synthesis. We have developed a Diels-Alder reaction of benzoquinones and 3-vinylindoles catalyzed by c

Regioselective synthesis of 4-substituted indoles via C-H activation: A ruthenium catalyzed novel directing group strategy

A highly regioselective functionalization of indole at the C-4 position by employing an aldehyde functional group as a directing group, and Ru as a catalyst, under mild reaction conditions (open flask) has been uncovered. This strategy to synthesize 4-substituted indoles is important, as this class of privileged molecules serves as a precursor for ergot alkaloids and related heterocyclic compounds.

Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines

The synthesis of several novel substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones structurally related to aplysinopsin have been carried out under microwave irradiation and conventional heating methods. The analogs 3a, 3b, 3d-3g, 3k and 3l were evaluated for their in vitro cytotoxic activity against an NCI 60 human tumor cell line panel. Compound 3f exhibited good growth inhibitory properties against all but four of the human cancer cell lines examined, and afforded LC50 values a cytotoxic agent. Thus, the aplysinopsin analog 3f was regarded as a useful lead compound for further structural optimization.