104944-23-2Relevant articles and documents
New method for the asymmetric reduction of ketophosphonates
Nesterov, Vitaly V.,Kolodiazhnyi, Oleg I.
, p. 687 - 688 (2008)
Chiral reducing reactants were prepared from lithium, sodium, or tetrabutylammonium borohydrides and (S)- or (R)-tartaric acids. Copyright Taylor & Francis Group, LLC.
Substrate-Based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase
Baguley, Tyler D.,Xu, Hai-Chao,Chatterjee, Manavi,Nairn, Angus C.,Lombroso, Paul J.,Ellman, Jonathan A.
, p. 7636 - 7650 (2013/11/06)
High levels of striatal-enriched protein tyrosine phosphatase (STEP) activity are observed in a number of neuropsychiatric disorders such as Alzheimer's disease. Overexpression of STEP results in the dephosphorylation and inactivation of many key neuronal
Synthesis of optically active hydroxyphosphonates
Guliaiko, Irina,Nesterov, Vitaly,Sheiko, Sergei,Kolodiazhnyi, Oleg I.,Freytag, Matthias,Jones, Peter G.,Schmutzler, Reinhard
, p. 133 - 139 (2008/09/18)
The reduction of dimenthyl ketophosphonates with sodium borohydride involves asymmetric induction at the a-carbon atom, resulting in a small excess of the (R)-enantiomer of the a-hydroxyphosphonate formed. A higher ee purity was achieved if the reduction