1049672-77-6 Usage
Description
1H-Pyrazolo[3,4-c]pyridin-5(6H)-one is an aromatic heterocyclic compound characterized by the fusion of a pyrazolo and pyridine ring. It possesses unique chemical properties due to the presence of nitrogen atoms in its structure, which allows it to form stable complexes with metal ions and participate in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
1H-Pyrazolo[3,4-c]pyridin-5(6H)-one is used as a pharmaceutical intermediate for the synthesis of various drugs. Its ability to bind to heme iron makes it a potential candidate for the development of inhibitors targeting cytochrome P450 enzymes, which play a crucial role in drug metabolism and detoxification processes.
Used in Chemical Research:
1H-Pyrazolo[3,4-c]pyridin-5(6H)-one serves as a valuable building block in the synthesis of complex organic molecules and heterocycles. Its unique structural features and reactivity make it a versatile component in the design and synthesis of novel compounds with potential applications in various fields, including materials science, catalysis, and medicinal chemistry.
Used in Drug Development:
Due to its interaction with heme iron, 1H-Pyrazolo[3,4-c]pyridin-5(6H)-one can be utilized in the development of drugs that modulate the activity of cytochrome P450 enzymes. This can lead to the discovery of new therapeutic agents that can improve the efficacy and safety of existing medications or address unmet medical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 1049672-77-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,9,6,7 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1049672-77:
(9*1)+(8*0)+(7*4)+(6*9)+(5*6)+(4*7)+(3*2)+(2*7)+(1*7)=176
176 % 10 = 6
So 1049672-77-6 is a valid CAS Registry Number.
1049672-77-6Relevant articles and documents
NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives
Tsikouris, Orestis,Bartl, Tomas,Tousek, Jaromir,Lougiakis, Nikolaos,Tite, Tony,Marakos, Panagiotis,Pouli, Nicole,Mikros, Emmanuel,Marek, Radek
, p. 643 - 649 (2008/12/23)
Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential NI-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the NI-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn. Copyright
