1049863-26-4

Basic information

• Product Name: 1-cyclohexylmethyl-7-methoxy-3-({5-[4-(2-methoxyethyl)piperazin-1-yl]methyl}-[1,2,4]-thiadiazol-3-yl)-1H-indole trifluoroacetate
• Synonyms: 1-cyclohexylmethyl-7-methoxy-3-({5-[4-(2-methoxyethyl)piperazin-1-yl]methyl}-[1,2,4]-thiadiazol-3-yl)-1H-indole trifluoroacetate
• CAS NO: 1049863-26-4
• Molecular Weight: 597.702
• Mol File: 1049863-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-cyclohexylmethyl-7-methoxy-3-({5-[4-(2-methoxyethyl)piperazin-1-yl]methyl}-[1,2,4]-thiadiazol-3-yl)-1H-indole trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexylmethyl-7-methoxy-3-({5-[4-(2-methoxyethyl)piperazin-1-yl]methyl}-[1,2,4]-thiadiazol-3-yl)-1H-indole trifluoroacetate(1049863-26-4)
• EPA Substance Registry System: 1-cyclohexylmethyl-7-methoxy-3-({5-[4-(2-methoxyethyl)piperazin-1-yl]methyl}-[1,2,4]-thiadiazol-3-yl)-1H-indole trifluoroacetate(1049863-26-4)

Safety Data

• Hazardous Substances Data: 1049863-26-4(Hazardous Substances Data)

Upstream product

• 13484-40-7 1-(2-methoxyethyl)piperazine 
• 865712-50-1 methanesulfonic acid 3-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-[1,2,4]thiadiazol-5-ylmethyl ester 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

INDOLE DERIVATIVES

The invention relates to indole derivative having the general Formula I wherein A represents a 5-membered aromatic heterocyclic ring, wherein X1, X2 and X3 are independently selected from N, O, S and CH; Y represents CH2, O, S or SO2; R1 is H, (C1-4)-alkyl, (C1-4)alkyloxy, CN or halogen; R2, R2′, R3, R3′, R4, R4′, R5 and R5′ are independently hydrogen, (C1-4)alkyl (optionally substituted with OH) or CO—OR8; or one pair of geminal substituents R3 and R3′ or R5 and R5′ together represent a keto group, and the others are all hydrogen or (C1-4)alkyl; or R2 and R5 together represent a methylene or an ethylene bridge, and R2′, R3, R3′, R4, R4′ and R5′ are hydrogen; n is 1 or 2; R6 is H, (C1-4)alkyl (optionally substituted with OH(C1-4)alkyloxy, CO—NR9R10, CO—OR11 or 1,2,4-oxadiazol-3-yl), SO2NR12R13 or COOR14; R7 is H or halogen; R8 is (C1-4)alkyl; R9 and R10 are independently hydrogen, (C1-4)alkyl or (C3-7)cycloalkyl, the alkyl groups being optionally substituted with OH or (C1-4)alkyloxy; R11 is H or (C1-4)alkyl; R12 and R13 are independently H or (C1-4)alkyl; R14 is (C1-6)alkyl; or a pharmaceutically acceptable salt thereof, as agonists of the cannabinoid CB1 receptor, which can be used in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.