1050504-35-2Relevant articles and documents
Analogues of nucleosides: Synthesis of chiral pyrrolidin-2-ones or pyrrolidines-bearing nucleobases
Martelli, Gianluca,Monsignori, Antonella,Orena, Mario,Rinaldi, Samuele
, p. 1357 - 1364 (2014/07/22)
Novel analogues of nucleosides tethered on a chiral pyrrolidin-2-one were prepared, but the imide functionality was unstable under basic conditions. Thus, the carbonyl group was removed from pyrrolidin-2-one, and nucleoside analogues bearing a pyrrolidine ring were synthesized, which were unaffected under basic conditions. A nucleoside dimer was also obtained, bearing a carbamate linkage between two units.