105123-89-5

Basic information

• Product Name: 1-(4-methylphenyl)piperidin-4-one
• Synonyms: 1-(4-methylphenyl)piperidin-4-one;UKRORGSYN-BB BBV-066117;1-(4-methylphenyl)piperidin-4-one(SALTDATA: FREE);1-(4-Methylphenyl)-4-piperidinone
• CAS NO: 105123-89-5
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• Mol File: 105123-89-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 345.647°C at 760 mmHg
• Flash Point: 138.375°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1-(4-methylphenyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)piperidin-4-one(105123-89-5)
• EPA Substance Registry System: 1-(4-methylphenyl)piperidin-4-one(105123-89-5)

Safety Data

• Hazardous Substances Data: 105123-89-5(Hazardous Substances Data)

Usage

General Description

1-(4-methylphenyl)piperidin-4-one is a chemical compound with the molecular formula C13H17NO. It is a piperidinone derivative with a substituted phenyl group at the 1-position. 1-(4-methylphenyl)piperidin-4-one is used in the research and development of pharmaceuticals and as a building block in organic synthesis. It has potential biological activity and may act as a precursor in the synthesis of various drugs and other organic compounds. The compound has a wide range of applications in the field of medicinal chemistry and drug discovery, making it a valuable and versatile chemical in scientific research and industrial production.

InChI:InChI=1/C12H15NO/c1-10-2-4-11(5-3-10)13-8-6-12(14)7-9-13/h2-5H,6-9H2,1H3

Upstream product

• 119836-09-8 1-(4-tolyl)piperidin-4-ol 
• 624-31-7 4-tolyl iodide 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 3592-25-4 1,5-dichloropentan-3-one 
• 105123-88-4 N,N-di-(2-ethoxycarbonylethyl)-p-toluidine 

Downstream Products

• 154913-02-7 1-(4-Methylphenyl)-4-<(4-cyano-1-naphthyl)methylene>piperidine 
• 105123-90-8 1-<(2-chloro-4-methyl)phenyl>piperidin-4-one 
• 115012-45-8 1-N-[(2-chloro-4-methyl)phenyl]-4,4-dimethoxypiperidine 
• 105123-91-9 1-(2-Chloro-4-methylphenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 
• 105123-97-5 C₄₁H₄₆Cl₂N₅O₁₇P 
• 105123-95-3 1-[(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 105123-92-0 2'-O-[1-(2-Chloro-4-methylphenyl)-4-methoxypiperidin-4-yl]uridine 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

A New Synthesis of 1-Arylpiperidin-4-ols

1,5-Dichloropentan-3-ol (8), which is readily prepared from the corresponding ketone (7), reacts with 2-fluoro-, 4-methyl-, 2-chloro-, 3-chloro-, 4-chloro-, and 3-chloro-4-methyl-anilines in the presence of potassium carbonate and sodium iodide in dimethy