10516-09-3

Basic information

• Product Name: 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol
• Synonyms: 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol;5-[(2S)-1-Methylpyrrolidin-2-yl]pyridin-2(1H)-one;6-Hydroxynicotine;(S)-6-Hydroxy Nicotine;5-[(2S)-1-Methyl-2-pyrrolidinyl]-;5-[(2S)-1-Methyl-2-pyrrolidinyl]-2(1H)-pyridinone;L-6-Hydroxynicotine
• CAS NO: 10516-09-3
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.23
• Product Categories: Chiral Reagents;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Nicotine Derivatives;Chiral Reagents, Heterocycles, Metabolites & Impurities, Mutagenesis Research Chemicals, Nicotine Derivatives
• Mol File: 10516-09-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• PKA: 11.98±0.10(Predicted)
• CAS DataBase Reference: 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol(10516-09-3)
• EPA Substance Registry System: 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol(10516-09-3)

Safety Data

• Hazardous Substances Data: 10516-09-3(Hazardous Substances Data)

Usage

Description

5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol, also known as (S)-6-Hydroxy nicotine, is a metabolite of nicotine (N412450), which is a known carcinogen agent. It is a chemical compound with a unique structure that has potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol is used as a research compound for studying the metabolism and effects of nicotine, a carcinogen agent. Understanding its properties and interactions can help in the development of treatments and therapies for nicotine addiction and related health issues.
Used in Toxicology Research:
As a metabolite of a known carcinogen, 5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol is used in toxicology research to investigate the mechanisms of nicotine-induced carcinogenesis and to identify potential targets for cancer prevention and treatment.
Used in Chemical Synthesis:
5-[(2S)-1-Methyl-2α-pyrrolidinyl]pyridine-2-ol can be used as a starting material or intermediate in the synthesis of other chemical compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, or materials science.

Upstream product

• 54-11-5 nicotin 
• 2055-13-2 5-(N'-Methyl-2'-pyrrolidinyl)-2-hydroxy pyridine 
• 65-30-5 S-(-)-nicotine hemisulfate 

Downstream Products

• 7424-35-3 6-hydroxypseudooxynicotine 
• 112091-17-5 (S)-6-chloronicotine 

Relevant articles and documents

Method for the microbiological production of optical antipodes of 6-hydroxynicotine

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Renewable functionalized pyridines derived from microbial metabolites of the alkaloid (5)-nicotine

(S)-Nicotine, which is present in concentrations of 2-8 % in dried leaves of certain tobacco plants, was used as a starting material for the biocatalytic production of renewable functionalized pyridines. Key microbial metabolites of (5)-nicotine, such as 6-hydroxy-(5)-nicotine and 4-[(6-hydroxypyridine)-3-yl]-4-oxobutyrate were used in subsequent chemical steps for the preparation of a wide variety of 2,5-di- or 2,3,5-tri-substituted pyridines.