105293-89-8

Basic information

• Product Name: N,N-Dipropyl-1,4-phenylenediamine
• Synonyms: N,N-Dipropyl-1,4-phenylenediamine;p-(Dipropylamino)aniline;AKOS BBV-008955;1,4-BenzenediaMine, N1,N1-dipropyl-;N1,N1-Dipropylbenzene-1,4-diamine
• CAS NO: 105293-89-8
• Molecular Formula: C₁₂H₂₀N₂
• Molecular Weight: 192.304
• Mol File: 105293-89-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 155.5-156.5 °C(Press: 6 Torr)
• Appearance: /
• Density: 0.982±0.06 g/cm3(Predicted)
• PKA: 7.79±0.10(Predicted)
• CAS DataBase Reference: N,N-Dipropyl-1,4-phenylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dipropyl-1,4-phenylenediamine(105293-89-8)
• EPA Substance Registry System: N,N-Dipropyl-1,4-phenylenediamine(105293-89-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 105293-89-8(Hazardous Substances Data)

Usage

General Description

N,N-Dipropyl-1,4-phenylenediamine is a chemical compound commonly used in hair dye formulations as a coloring agent. It belongs to the group of aromatic diamines and is known for its ability to provide color stability and long-lasting results in hair coloring products. N,N-Dipropyl-1,4-phenylenediamine is also used in the manufacturing of some polymers and as an intermediate in the production of various chemicals and pharmaceuticals. However, it is important to note that N,N-Dipropyl-1,4-phenylenediamine should be handled with care as it may cause skin and eye irritation, and prolonged exposure to this chemical can lead to adverse health effects. Therefore, proper safety measures and handling protocols should be followed when using or working with this compound.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 142-84-7 di-n-propylamine 
• 7647-01-0 hydrogenchloride 
• 100316-72-1 4-nitroso-N,N-di-n-propylaniline 
• 49645-18-3 N,N-di-n-propyl-p-nitroaniline 

Downstream Products

• 854906-40-4 N,N'-bis-(4-dipropylamino-phenyl)-urea 
• 1512-06-7 N-(4-dipropylamino-phenyl)-N'-(4-fluoro-phenyl)-thiourea 
• 101715-32-6 4-(2,5-dimethyl-pyrrol-1-yl)-N,N-dipropyl-aniline 

Relevant articles and documents

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound 9q, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, 9q suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation.

3-substituted para-aminophenols

The invention concerns the use of a 3-substituted para-aminophenol as an oxidation dye precursor for dyeing keratinous fibres, in particular human hair. The 3-substituted para-aminophenol has formula: STR1 where R1 represents alkyl, alkenyl, mono- or polyhydroxyalkyl, nitrile, cyanoalkyl, halogenoalkyl, aminoalkyl or alkoxyalkyl and R2 represents hydrogen, alkyl or mono- or polyhydroxyalkyl, provided that when R2 is hydrogen R1 is not methyl or trifluoromethyl, and to addition salts thereof with an acid. The invention also concerns dye compositions containing compound (I). The invention further concerns novel 3-substituted para-aminophenols.