1053661-92-9

Basic information

• Product Name: N-[1-(3-pyridyl)ethylidene]-N'-[4-(2-hydroxy-5-methoxyphenyl)thiazol-2-yl]hydrazine
• CAS NO: 1053661-92-9
• Molecular Weight: 340.406
• Mol File: 1053661-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-(3-pyridyl)ethylidene]-N'-[4-(2-hydroxy-5-methoxyphenyl)thiazol-2-yl]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(3-pyridyl)ethylidene]-N'-[4-(2-hydroxy-5-methoxyphenyl)thiazol-2-yl]hydrazine(1053661-92-9)
• EPA Substance Registry System: N-[1-(3-pyridyl)ethylidene]-N'-[4-(2-hydroxy-5-methoxyphenyl)thiazol-2-yl]hydrazine(1053661-92-9)

Safety Data

• Hazardous Substances Data: 1053661-92-9(Hazardous Substances Data)

Upstream product

• 203524-87-2 1-(2-hydroxy-5-methoxyphenyl)-2-bromoethanone 
• 13370-86-0 2-[1-(pyridine-3-yl)ethylidene]hydrazinecarbothioamide 

Relevant articles and documents

Synthesis and antituberculosis activity of some N-pyridyl-N′-thiazolylhydrazine derivatives

In this study, new N-(1-arylethylidene)-N′-(4-arylthiazol-2-yl)hydrazine derivatives were synthesized and evaluated for their antituberculosis activity. The chemical structures of the compounds were elucidated by IR, NMR and FAB+-MS spectral data and Elemental Analyses. The initial screen was conducted against Mycobacterium tuberculosis H37Rv (ATCC 27294) in BACTEC 12B medium using the Microplate Alamar Blue Assay (MABA). The VERO cell cytotoxicity assay was done in parallel with the TB Dose Response assay. Viability was assessed using Promega's Cell Titer-Glo Luminescent Cell Viability Assay. Cytotoxicity was determined from the dose-response curve as the CC50 using a curve-fitting program. One of the compounds showed high activity with low toxicity.