10543-12-1

Basic information

• Product Name: 4-Acetoxy-3-methoxybenzoic acid
• Synonyms: 4-(acetyloxy)-3-methoxy-benzoicaci;Benzoic acid, 4-(acetyloxy)-3-methoxy-;RARECHEM AL BE 0061;O-ACETYLVANILLIC ACID;3-METHOXY-4-ACETOXYBENZOIC ACID;4-ACETOXYBENZOIC ACID, METHYL ETHER;4-ACETOXY-3-METHOXYBENZOIC ACID;4-ACETYLVANILLIC ACID
• CAS NO: 10543-12-1
• Molecular Formula: C₁₀H₁₀O₅
• Molecular Weight: 210.18
• EINECS: 234-122-2
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 10543-12-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 149 °C
• Boiling Point: 327.95 °C at 760 mmHg
• Flash Point: 128.065 °C
• Appearance: /
• Density: 1.285 g/cm³
• Vapor Pressure: 7.91E-05mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.93±0.10(Predicted)
• CAS DataBase Reference: 4-Acetoxy-3-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetoxy-3-methoxybenzoic acid(10543-12-1)
• EPA Substance Registry System: 4-Acetoxy-3-methoxybenzoic acid(10543-12-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10543-12-1(Hazardous Substances Data)

Usage

General Description

4-Acetoxy-3-methoxybenzoic acid, also known as methyl acetoxysalicylate, is a chemical compound with the molecular formula C10H10O5. It belongs to the class of organic compounds known as phenolic glycosides and is derived from salicylic acid. 4-Acetoxy-3-methoxybenzoic acid is commonly used in the field of medicine for its anti-inflammatory and analgesic properties. It is also used in the production of various pharmaceuticals and cosmetics. Additionally, it has been studied for its potential use in combating various medical conditions, including cancer and cardiovascular diseases.

InChI:InChI=1/C10H10O5/c1-6(11)15-8-4-3-7(10(12)13)5-9(8)14-2/h3-5H,1-2H3,(H,12,13)

Upstream product

• 79-21-0 peracetic acid 
• 881-68-5 vanillin acetate 
• 104-15-4 toluene-4-sulfonic acid 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 1135-24-6 3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 121-33-5 vanillin 
• 97-53-0 4-allylguaiacol 
• 93-07-2 Veratric acid 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 5447-38-1 2-(4-acetoxy-3-methoxyphenyl)acetic acid 
• 60-29-7 diethyl ether 
• 5912-87-8 (E)-1-(4-acetoxy-3-methoxyphenyl)-1-propene 

Downstream Products

• 121965-37-5 O¹-(4-acetoxy-3-methoxy-benzoyl)-O²,O³,O⁴-triacetyl-O⁶-(toluene-4-sulfonyl)-β-D-glucopyranose 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 64-19-7 acetic acid 
• 1431884-50-2 6-acetoxy-7-methoxy-3,4-diphenylisocoumarin 
• 1041740-13-9 3,6-furan-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenylheptane 
• 90-05-1 2-methoxy-phenol 

Relevant articles and documents

ACYLRESORCINOLS FROM SEED KERNELS OF MYRISTICA DACTYLOIDES

A new polyketide 1-(2,6-dihydroxyphenyl)-9-(4-hydroxy-3-methoxyphenyl)nonan-1-one and five other polyketides 1-(2,6-dihydroxyphenyl)tetradecan-1-one and malabaricones A-D have been isolated from Myristica dactyloides seeds. 13C NMR of the first and the second mentioned compounds are also reported for the first time.Key Word Index - Myristica dactyloides; Myristicaceae; seeds; polyketides; 13C NMR.

Aromatic thermotropic polyesters based on 2,5-furandicarboxylic acid and vanillic acid

This paper addresses a route to synthesize bio-based polymers with an aromatic backbone having a liquid crystalline (LC) phase in the molten state. The LC phase is employed to achieve uniaxial orientation during processing required in e.g. fiber spinning. For this purpose 2,5-furandicarboxylic acid (2,5-FDCA) and O-acetylvanillic acid (AVA), obtained from natural resources, are used as monomers. Similar to the 2,6-hydroxynapthoic acid used to perturb the crystalline packing of poly(oxybenzoate) in the Vectran series, these bio-based monomers are used to lower the crystal to liquid crystal transition temperature. Considering that the poly(oxybenzoate) can also be obtained from natural resources, the adopted route provides the unique possibility to synthesize bio-based polymers that can be used for high performance applications. To obtain the desired polymers, a synthetic route is developed to overcome the thermal instability of the 2,5-FDCA monomer. Experimental techniques, such as optical microscopy, FTIR spectroscopy, DSC, and TGA are employed to follow the polymerization, phase transitions and evaluate thermal stability of the synthesized polymers.

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Vanillic amide derivative, and preparation method and application thereof

The invention relates to a vanillic amide derivative as shown in a formula I which is described in the specification and pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the vanillic amide derivative and the pharmaceutically acceptable salt of the vanillic amide derivative, and an application of the vanillic amide derivative, the pharmaceutically acceptable salt ofthe vanillic amide derivative and the pharmaceutical composition in preparation of an influenza virus neuraminidase inhibitor. In the formula I, R2 is Me or t-Bu; and R3 is selected from the group consisting of CO2Et, COCH3, imidazolyl, 1,2,4-triazolyl and C(= NOCH3)CH3.

A Convergent Total Synthesis of the Biologically Active Benzofurans Ailanthoidol, Egonol and Homoegonol from Biomass-Derived Eugenol

An efficient, general synthetic protocol for the synthesis of the biologically active benzofurans ailanthoidol, egonol and homoegonol was developed. The key starting material, eugenol, is a naturally occurring and abundant precursor. The protocol, involving sequential acylation and intramolecular Wittig reaction, provides a convenient method for building the benzofuran moiety in good yield.