10547-60-1

Basic information

• Product Name: 4-chloro-4'-methoxybenzophenone
• Synonyms: 4-(4-Chlorobenzoyl)phenylmethyl ether;4-Chlorophenyl 4-methoxyphenyl ketone;4-Methoxy-4'-chlorobenzophenone;Einecs 234-131-1;Nsc 74662;(4-chlorophenyl)(4-methoxyphenyl)methanone(SALTDATA: FREE);Methanone, (4-chlorophenyl)(4-Methoxyphenyl)-;(4-chlorophenyl)(4-Methoxyphenyl)MethaNAne
• CAS NO: 10547-60-1
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.7
• EINECS: 234-131-1
• Mol File: 10547-60-1.mol
• Article Data: 85

Chemical Properties

• Melting Point: 124-125 °C
• Boiling Point: 380.5°Cat760mmHg
• Flash Point: 157.6°C
• Appearance: /
• Density: 1.212g/cm³
• CAS DataBase Reference: 4-chloro-4'-methoxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-4'-methoxybenzophenone(10547-60-1)
• EPA Substance Registry System: 4-chloro-4'-methoxybenzophenone(10547-60-1)

Safety Data

• Hazardous Substances Data: 10547-60-1(Hazardous Substances Data)

Usage

Uses

4-Chlroro-4’-methoxybenzophenone is a chemical reagent used in the preparation of photosensitizers and UV filters.

Preparation

Obtained by reaction of 4-chlorobenzoyl chloride with anisole in the presence of –MoO2Cl2 (20 mol%) at reflux for 20 h (75%).

Upstream product

• 13392-79-5 1-chloro-4-(1-(4-methoxyphenyl)vinyl)benzene 
• 76024-67-4 2,4-bis(4-chlorobenzoyl)-1-methylpyrrole 
• 100-66-3 methoxybenzene 
• 74-11-3 para-chlorobenzoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1228460-45-4 C₂₁H₁₈N₂O₆ 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 106-39-8 bromochlorobenzene 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 37155-52-5 1-(4-chlorobenzyl)-4-methoxybenzene 
• 619-56-7 4-chlorobenzamide 

Downstream Products

• 13392-79-5 1-chloro-4-(1-(4-methoxyphenyl)vinyl)benzene 
• 31545-27-4 4-chloro-4'-methoxy-3-nitrobenzophenone 
• 1374583-94-4 (4-chlorophenyl)(4-methoxyphenyl)pyridin-3-yl methanol 
• 1448819-43-9 1-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-ol 
• 34979-37-8 (4-chlorophenyl)(4-methoxyphenyl)methanol 
• 71240-35-2 1-(4-Chloro-phenyl)-2,2,2-tris-(4-methoxy-phenyl)-ethanone 

Relevant articles and documents

DDQ/tert-Butyl nitrite-catalyzed aerobic oxidation of diarylmethane sp3 C-H bonds

An efficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone/tert-butyl nitrite-catalyzed aerobic oxidation of diarylmethane sp3 C-H bonds in the presence of acetic acid has been developed. Under the optimal reaction conditions, a number of diarylmethanes can be directly converted to their corresponding diarylketones in good to excellent yields. In addition, a plausible reaction mechanism has been investigated.

Copper-catalyzed carbonylative Suzuki coupling of aryl iodides with arylboronic acids under ambient pressure of carbon monoxide

An efficient and ligandless nanocopper-catalyzed carbonylative cross-coupling of aryl iodides with arylboronic acids at ambient CO pressure in poly(ethylene glycol), has been developed. This protocol is general, practical, and recyclable, and offers an attractive alternative to the corresponding palladium-mediated carbonylative Suzuki process for the construction of biaryl ketone scaffolds.

Exploring the Reducing Ability of Organic Dye (Acr+-Mes) for Fluorination and Oxidation of Benzylic C(sp3)-H Bonds under Visible Light Irradiation

The excellent oxidizing capability of acridinium-based organic dye (Acr+-Mes) is fully studied in photoredox catalysis. However, its reducing ability is always considered weak for organic transformation. The reducing ability of Acr+-Mes is developed by Selectfluor to achieve effective fluorination and oxidation of benzylic C(sp3)-H bonds under visible light irradiation, which is not available for the direct use of oxidizing ability of excited Acr+-Mes. Mechanistic insights provided strong evidence for the oxidative quenching of Acr+-Mes.

T-BuONa-Mediated Transition-Metal-Free Autoxidation of Diarylmethanes to Ketones

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Agglomeration of Pd0 nanoparticles causing different catalytic activities of Suzuki carbonylative cross-coupling reactions catalyzed by PdII and Pd0 immobilized on dopamine-functionalized magnetite nanoparticles

Solvent-dispersible magnetite nanoparticles (Fe3O4) end-functionalized with amino groups were successfully prepared by a facile one-pot template-free method to immobilize PdII and Pd0 using a metal adsorption and reduction procedure. They were characterized by TEM, XRD, XPS, FT-IR and VSM. Interestingly, the PdII catalyst exhibited better catalytic activity for carbonylative cross-coupling reactions than the Pd0 catalyst. According to the catalytic activities of a variety of arylboronic acids and aryl iodides catalyzed by two kinds of Pd catalysts, the proposed reaction mechanism of Suzuki carbonylative cross-coupling reactions using the Pd catalyst was also inferred. More importantly, agglomeration of Pd0 nanoparticles was obviously observed in the TEM images of the catalysts after reactions. Therefore, agglomeration of Pd0 nanoparticles should be considered as a significant reason for different catalytic activities of the reactions catalyzed by immobilized PdII and Pd0 catalysts. Furthermore, the PdII catalyst revealed high efficiency and stability during recycling stages.

Dirhodium(II)-Catalyzed Cross-Coupling Reactions of Aryl Aldehydes with Arylboronic Acids in Water

In this report, dirhodium(II) catalysts with axial phosphanes ligands were employed to catalyze cross-coupling reactions of aromatic aldehydes with arylboronic acids to generate ketones in neat water. The overall reaction is proposed to occur through a cascade process involving the dirhodium-catalyzed addition of boronic acids to aldehydes followed by the dehydrogenative oxidation of alcohols.

Ligandless heterogeneous palladium: An efficient and recyclable catalyst for Suzuki-type cross-coupling reaction

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Preparation of recoverable Fe3O4@PANI-PdII core/shell catalysts for Suzuki carbonylative cross-coupling reactions

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Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes

The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.

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Method for preparing diarylketone compound through efficient catalysis of pyridine palladium

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