105500-29-6

Basic information

• Product Name: Carbamic acid, [2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-
• CAS NO: 105500-29-6
• Molecular Formula: C19H22N2O3
• Molecular Weight: 326.395
• Mol File: 105500-29-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(105500-29-6)
• EPA Substance Registry System: Carbamic acid, [2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(105500-29-6)

Safety Data

• Hazardous Substances Data: 105500-29-6(Hazardous Substances Data)

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 506-59-2 N,N-dimethylammonium chloride 
• 100-39-0 benzyl bromide 
• 810671-46-6 C₂₆H₃₈N₂O₄ 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 124-40-3 dimethyl amine 

Downstream Products

• 121253-53-0 2-ethoxy-5-phenyl-4-<<(phenylmethoxy)carbonyl>amino>-3-oxo-1-pentene 
• 128302-56-7 C₆₂H₇₄N₁₄O₁₂ 
• 128302-56-7 C₆₂H₇₄N₁₄O₁₂ 
• 121638-08-2 2,8-Bis<(N-carbonyl-Gly-Phe-NMe2)-Pro-D-Ala-NH>epindolidione 
• 128302-57-8 C₅₆H₆₆N₁₄O₁₂ 
• 128326-89-6 C₆₄H₇₈N₁₄O₁₂ 
• 128302-52-3 C₅₈H₆₆N₁₄O₁₂ 
• 609367-15-9 (R)-2-[(Benzyloxy-formyl-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2-phenyl-ethyl)-amide 
• 111491-96-4 (S)-3-(N-(benzyloxycarbonyl)amino)-4-phenyl-2-butanone 
• 29618-17-5 L-phenylalanine dimethylamide 
• 104347-81-1 L-Phenylalanine Dimethylamide Hydrobromide 

Relevant articles and documents

Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine

Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1S,2R)-tranylcypromine as an antidepressant medicine via Lossen rearrangement.

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the P2′ and P3′ side chains

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to both the P2′ and P3′ side chains. Enzyme inhibition and antibacterial activity data revealed that a variety of substituents are tolerated at the P2′ and P3′ positions of the inhibitor backbone. The data from this study highlights the potential for modification at the P2′ and P3′ positions to optimise the physicochemical properties.

Tumor retarding (1-benzyl-ethylenediamine)-platin (II)-complexes

There are described (1-benzylethylenediamine)-platin(II)-complexes of the general formula: STR1 wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1 -C6