10563-29-8 Usage
Description
N,N-Dimethyldipropylenetriamine (ATOFI) is an aliphatic acyclic amine that is commonly used to develop polymeric systems for gene delivery. It possesses unique chemical properties that make it suitable for various applications in different industries.
Uses
1. Used in Pharmaceutical Industry:
N,N-Dimethyldipropylenetriamine (ATOFI) is used as a building block for the development of biodegradable amphiphilic polycationic copolymers, such as poly(ethylene oxide)-b-poly(3-caprolactone-g-DP) [PEO-b-P(CL-g-DP)]. These copolymers have potential applications in drug delivery and gene therapy.
2. Used in Enzyme Inhibition:
N,N-Dimethyldipropylenetriamine (ATOFI) is used as a key component in the development of a second-generation aminoglycoside 6′-N-acetyltransferase (AAC(6′)) inhibitor. This inhibitor can help in the treatment of bacterial infections by blocking the action of aminoglycoside-resistant enzymes.
3. Used in Cancer Treatment:
N,N-Dimethyldipropylenetriamine (ATOFI) is used in the preparation of a hydrophilic gemcitabine conjugated cationic copolymer, which can be employed in the treatment of pancreatic cancer. This copolymer can improve the drug's solubility, bioavailability, and therapeutic efficacy.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 10563-29-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,6 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10563-29:
(7*1)+(6*0)+(5*5)+(4*6)+(3*3)+(2*2)+(1*9)=78
78 % 10 = 8
So 10563-29-8 is a valid CAS Registry Number.
10563-29-8Relevant articles and documents
Method for preparing pentamethyldipropylene triamine
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Paragraph 0065; 0068; 0070; 0072; 0075; 0077, (2019/11/20)
The invention provides a method for preparing pentamethyldipropylene triamine. The method comprises the following steps: (1) performing a reaction on 3-dimethylaminopropylamine and acrylonitrile so asto form a 3-[[3-(dimethylamino)propyl]amino]propionitrile reaction solution, and performing separation so as to obtain a 3-[[3-((dimethylamino)propyl]amino]propionitrile pure product; (2) performinga hydrogenation reaction on 3-[[3-(dimethylamino)propyl]amino]propionitrile, hydrogen and a solvent under the action of a catalyst so as to obtain a N'-(3-aminopropyl)-N,N-dimethyl-1,3-propylene diamine reaction solution; and (3) performing a methylation reaction on the N'-(3-aminopropyl)-N,N-dimethyl-1,3-propylene diamine reaction solution obtained in the step (2), formaldehyde and hydrogen underthe action of a catalyst so as to obtain pentamethyldipropylene triamine. The method has the advantages of cheap and easily available starting materials, good selectivity to the product and high product yield, and the method is economical and effective, and has industrialization prospects.