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105763-54-0

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105763-54-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 105763-54-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,6 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 105763-54:
(8*1)+(7*0)+(6*5)+(5*7)+(4*6)+(3*3)+(2*5)+(1*4)=120
120 % 10 = 0
So 105763-54-0 is a valid CAS Registry Number.

105763-54-0Relevant articles and documents

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide

Jones,Venuti,Alvarez,Bruno,Berks,Prince

, p. 295 - 303 (2007/10/02)

Evaluation of a series of lactam heterocyclic analogues of cilostamide as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding methoxy-substituted heterocycles has revealed that the N-cyclohexyl-N-methyl-4-oxybutyramide side chain of 2 is an important lipophilic and/or steric pharmacophore. Attachment of this side chain to the parent heterocycle of the potent cyclic AMP phosphodiesterase inhibitor anagrelide afforded the hybrid structure RS-82856, shown to be more potent than either of its progenitors as an inhibitor of cyclic AMP phosphodiesterase or of ADP-induced platelet aggregation. The available in vitro data suggest that 1 possesses potentially useful antithrombotic and cardiotonic properties.

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