105851-17-0

Basic information

• Product Name: Fludeoxyglucose F 18
• Synonyms: (2S,3R,4S,5R,6R)-3-fluoro-6-(hydroxymethyl)oxane-2,4,5-triol;2-(Fluoro-18F)-2-deoxy-alpha-glucopyranose;Fludeoxyglucose F 18;2-(18F)Fluoro-2-deoxy-α-D-glucopyranose;2-Deoxy-2-(18F)fluoro-α-D-glucopyranose;alpha-D-Glucopyranose, 2-deoxy-2-(fluoro-18F)-;Fludeoxyglucose (18F)-;Fluorodeoxyglucose F18
• CAS NO: 105851-17-0
• Molecular Formula: C6H11FO5
• Molecular Weight: 181.148
• Mol File: 105851-17-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 413.6 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.59 g/cm3
• Refractive Index: 1.535
• CAS DataBase Reference: Fludeoxyglucose F 18(CAS DataBase Reference)
• NIST Chemistry Reference: Fludeoxyglucose F 18(105851-17-0)
• EPA Substance Registry System: Fludeoxyglucose F 18(105851-17-0)

Safety Data

• Hazardous Substances Data: 105851-17-0(Hazardous Substances Data)

Usage

Uses

Diagnostic aid; radioactive agent.

InChI:InChI=1/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2/t2-,3-,4-,5-,6+/m1/s1/i7-1

Upstream product

• 105285-83-4 2-deoxy-2-[⁽¹⁸⁾F]fluoro-1,3,4,6-tetra-O-acetyl-D-glucose 
• 92051-23-5 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose 
• 21193-75-9 D-galactal 
• 110824-72-1 C₁₄H₁₉⁽¹⁸⁾FO₉ 
• 84766-01-8 1,2-anhydro-3,4:5,6-di-O-isopropylidene-1-C-nitro-D-mannitol 
• 94715-29-4 2-deoxy-2-<18F>fluoro-3,4:5,6-di-O-isopropylidene-aldehydo-D-glucose 
• 13265-84-4 D-glucal 
• 128441-61-2 1,3,4,6-tetra-O-acetyl-2-deoxy-2-<18F>fluoro-D-glucopyranose 
• 67470-60-4 3,4,6-tri-O-acetyl-2-deoxy-2-<18F>fluoro-α-D-glucopyranosyl <18F>fluoride 
• 84243-95-8 1,3,4,6-tetra-O-acetyl-2-deoxy-2-<18F>fluoro-D-mannopyranose 
• 67470-61-5 3,4,6-tri-O-acetyl-2-deoxy-2-<18F>fluoro-β-D-mannopyranosyl <18F>fluoride 

Relevant articles and documents

Synthesis of 18F-labelled 2-deoxy-2-fluoro-D-galactopyranose using the acetyl hypofluorite procedure

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Chemoenzymatic n.c.a synthesis of the coenzyme UDP-2-deoxy-2-( 18F)fluoro-α-D-glucopyranose as substrate of glycosyltransferases

The development of 18F-labelling methods adopted to proteins and bioactive peptides is of great interest in radiopharmaceutical sciences. In order to provide 18F-labelled sugars as a polar prosthetic group for an enzymatic 18F-labelling procedure, an appropriate nucleotide activated sugar is needed. Here, we present the radiosynthesis of n.c.a. UDP-2-deoxy-2-[18F]fluoro-α-D-glucopyranose (UDP-[ 18F]FDG) as a substrate for glycosyltransferases. The MacDonald synthesis of [18F]FDG-1-phosphate was successfully combined with an enzymatic activation to obtain UDP-[18F]FDG directly in an aqueous medium located in the void volume of a solid phase cartridge. The radiochemical yield of UDP-[18F]FDG was 20% (based on [18F]fluoride) after a total synthesis time of 110 min. Thus, an intermediate was provided for the enzymatic transfer of [18F]FDG using UDP-[18F]FDG as glycosyl donor making use of a suitable glycosyltransferase. This would represent a highly selective and mild 18F-labelling method for glycosylated biomolecules. Copyright

DEVICE AND METHOD FOR THE PRODUCTION OF RADIOCHEMICAL COMPOUNDS

The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module;the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; andat least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module.

MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the positi