1058721-80-4Relevant articles and documents
Preference of β-lactam formation in Cu(I)-catalyzed intramolecular coupling of amides with vinyl bromides
Zhao, Qiwu,Li, Chaozhong
supporting information; experimental part, p. 4037 - 4040 (2009/05/27)
(Chemical Equation Presented) A general and highly efficient synthesis of 4-alkylidene-2-azetidinones was achieved by the Cu(I)-catalyzed intramolecular C-N coupling of amides with vinyl bromides. This 4-exo ring closure was found to be fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo) of cyclization under copper catalysis. Tandem C-N bond formation was then successfully developed to allow the convenient generation of medium-sized lactams.