1059734-66-5 Usage
Description
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.
Check Digit Verification of cas no
The CAS Registry Mumber 1059734-66-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,9,7,3 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1059734-66:
(9*1)+(8*0)+(7*5)+(6*9)+(5*7)+(4*3)+(3*4)+(2*6)+(1*6)=175
175 % 10 = 5
So 1059734-66-5 is a valid CAS Registry Number.
1059734-66-5Relevant articles and documents
INHIBITORS OF THE HEDGEHOG PATHWAY
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, (2008/12/07)
The present invention is directed to a compound of Formula (I) or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula (I) to treat cancer.
