106366-30-7

Basic information

• Product Name: 2-(2-PHENYLETHYL)PYRROLIDINE
• Synonyms: 2-PHENETHYL-PYRROLIDINE;2-(2-PHENYLETHYL)PYRROLIDINE
• CAS NO: 106366-30-7
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27
• Mol File: 106366-30-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 270.3 °C at 760 mmHg
• Flash Point: 118.3 °C
• Appearance: /
• Density: 0.957 g/cm³
• Vapor Pressure: 0.00688mmHg at 25°C
• Refractive Index: 1.519
• PKA: 10.93±0.10(Predicted)
• CAS DataBase Reference: 2-(2-PHENYLETHYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-PHENYLETHYL)PYRROLIDINE(106366-30-7)
• EPA Substance Registry System: 2-(2-PHENYLETHYL)PYRROLIDINE(106366-30-7)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22
• Hazardous Substances Data: 106366-30-7(Hazardous Substances Data)

Usage

General Description

2-(2-Phenylethyl)pyrrolidine is a chemical compound also known as PEP. It is a pyrrolidine derivative that contains a phenylethyl group, which is a common structure found in many psychoactive drugs. PEP is known to have stimulant and euphoric effects, and is sometimes used recreationally. It is also used in scientific research as a building block for the synthesis of other compounds. PEP has a unique chemical structure that makes it an interesting target for study, and its psychoactive properties make it a subject of interest for both recreational users and researchers alike.

InChI:InChI=1/C12H17N/c1-2-5-11(6-3-1)8-9-12-7-4-10-13-12/h1-3,5-6,12-13H,4,7-10H2

Upstream product

• 346423-31-2 2-(3-azido-5-phenylpentyl)-1,3-dioxolane 
• 346423-24-3 1-(1,3-dioxolan-2-yl)-5-phenylpentan-3-ol 
• 103-63-9 1-phenyl-2-bromoethane 
• 6628-68-8 ethyl 2-(ethoxycarbonyl)-4-phenylbutanoate 
• 1567842-73-2 C₂₅H₃₉N₃O₆ 
• 346423-32-3 1-(2-[1,3]dioxolan-2-yl-ethyl)-3-phenyl-propylamine 
• 106366-23-8 2-(1-phenylethyl)-3,4-dihydro-5H-pyrrole 

Downstream Products

• 1567843-71-3 C₁₃H₁₉N₃*ClH 
• 1570523-35-1 C₁₃H₁₉N₃ 
• 613676-51-0 2-methyl-5-{[2-(2-phenylethyl)-1-pyrrolidinyl]carbonyl} pyridine 

Relevant articles and documents

DIRECT C-H AMINATION AND AZA-ANNULATION

In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships

We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, 1-3, having the 3- arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of 9h, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner.

THE PREPARATION OF "ELONGATED" NICOTINE ANALOGUES

The preparation of four nicotine analogues having one or two additional methylene units between the N-methylpyrrolidinyl moiety and the aromatic ring are reported.Also prepared are the corresponding nornicotine and myosmine analogues.The course of the Spa