106376-18-5

Basic information

• Product Name: N-phenyl-3-(trifluoromethyl)benzamide
• Synonyms: N-phenyl-3-(trifluoromethyl)benzamide
• CAS NO: 106376-18-5
• Molecular Formula: C₁₄H₁₀F₃NO
• Molecular Weight: 265.2305096
• Mol File: 106376-18-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-phenyl-3-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-3-(trifluoromethyl)benzamide(106376-18-5)
• EPA Substance Registry System: N-phenyl-3-(trifluoromethyl)benzamide(106376-18-5)

Safety Data

• Hazardous Substances Data: 106376-18-5(Hazardous Substances Data)

Upstream product

• 76783-59-0 ethyl 3-(trifluoromethyl)benzoate 
• 62-53-3 aniline 
• 98-80-6 phenylboronic acid 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 
• 3422-01-3 tert-butyl phenylcarbamate 
• 18992-89-7 allyl N-phenylcarbamate 
• 103-71-9 phenyl isocyanate 
• 723252-38-8 C₁₄H₉ClF₃NO 
• 98-95-3 nitrobenzene 
• 201230-82-2 carbon monoxide 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 58710-61-5 phenyl 3-(trifluoromethyl)benzoate 
• 368-77-4 3-trifluoromethylbenzonitrile 
• 591-50-4 iodobenzene 

Downstream Products

• 350487-59-1 N'-methoxy-N-phenyl-3-(trifluoromethyl)benzimidamide 
• 1609460-47-0 1-benzyl-2-(3-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole 
• 1609460-29-8 N-benzyl-N'-phenyl-3-(trifluoromethyl)benzimidamide 
• 1372890-84-0 4-phenyl-2-(3-(trifluoromethyl)phenyl)quinazoline 
• 425366-00-3 N-phenyl-3-trifluoromethyl-benzimidic acid 4-cyano-phenyl ester 
• 425366-16-1 phenyl-(3-trifluoromethyl-phenylmethylidyne)-ammonium 

Relevant articles and documents

Role of intermolecular interactions involving organic fluorine in trifluoromethylated benzanilides

Trifluoromethylated benzanilides, containing C(sp3)-F bonds, have been synthesized and their crystal and molecular structures have been investigated to highlight the significance of weak intermolecular interactions associated with the presence

Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source

In present work, we have explored a Cu(acac)2/vasicine-catalyzed regioselective hydrodehalogenation methodology of o-haloanilides using EtOH as hydrogen source and solvent. The catalytic system could selectively dehalogenate 2-Br and 2-I, and features regioselective, efficient and functional group tolerance.

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.