106614-28-2

Basic information

• Product Name: METHYL 2,4-DIFLUOROBENZOATE
• Synonyms: RARECHEM AL BF 0213;METHYL 2,4-DIFLUOROBENZOATE;2,4-DIFLUORO-BENZOIC ACID METHYL ESTER;Methyl 2,4-difluorobenzoate ,97%;Methyl 2,4-difluorobenzoate 97%
• CAS NO: 106614-28-2
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• EINECS: 1592732-453-0
• Product Categories: Aromatic Esters;Acids & Esters;Fluorine Compounds;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 106614-28-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 128-129 °C(lit.)
• Flash Point: 180 °F
• Appearance: /
• Density: 1.384 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.354mmHg at 25°C
• Refractive Index: n20/D 1.4840(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2,4-DIFLUOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,4-DIFLUOROBENZOATE(106614-28-2)
• EPA Substance Registry System: METHYL 2,4-DIFLUOROBENZOATE(106614-28-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 106614-28-2(Hazardous Substances Data)

Usage

Description

METHYL 2,4-DIFLUOROBENZOATE is a colorless to yellow liquid that serves as a crucial reagent in the pharmaceutical industry. It is primarily utilized in the synthesis of various pharmaceutical compounds, including integrin αvβ3 antagonists that exhibit antiplatelet activity.

Uses

Used in Pharmaceutical Industry:
METHYL 2,4-DIFLUOROBENZOATE is used as a reagent for the synthesis of pharmaceuticals, specifically in the development of integrin αvβ3 antagonists. These antagonists are known for their antiplatelet activity, which can be beneficial in the treatment and prevention of blood clot-related conditions.
Used in the Design and Synthesis of Integrin Antagonists:
METHYL 2,4-DIFLUOROBENZOATE plays a significant role in the design and synthesis of integrin αvβ3 antagonists. These compounds have the potential to inhibit the aggregation of platelets, which can be crucial in managing and treating various cardiovascular diseases and conditions related to blood clotting.

InChI:InChI=1/C8H6F2O2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3

Upstream product

• 367-27-1 2,4-difluorophenol 
• 67-56-1 methanol 
• 15226-74-1 dicobalt octacarbonyl 
• 264135-49-1 2,4-difluorophenyl trifluoromethanesulfonate 
• 729559-69-7 N-(4-cyanophenyl)-2,4-difluorobenzamide 
• 13656-36-5 3,5-dichloro-2,4,6-trifluorobenzoic acid 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 124-38-9 carbon dioxide 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 74-88-4 methyl iodide 
• 72482-64-5 2,4-difluorobenzoyl chloride 

Downstream Products

• 129793-82-4 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)ethanone 
• 234082-13-4 methyl 2-fluoro-4-(piperazin-1-yl)benzoate 
• 1012867-16-1 2-Fluoro-4-dimethylamino-benzoic acid methyl ester 
• 553672-28-9 methyl 2-fluoro-4-(4-thiomorpholinyl)benzoate 
• 942468-42-0 2-fluoro-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester 
• 942468-43-1 4-fluoro-2-{4-methyl-piperazin-1-yl}-benzoic acid methyl ester 
• 1001922-34-4 1-(2,4-difluorophenyl)-2-(2-methylsulfanylpyrimidin-4-yl)ethanone 
• 128272-26-4 [13C₂, D₇]2-(2-fluoro-4-methoxyphenyl)propan-2-ol 
• 204707-42-6 methyl 4-fluoro-2-methoxybenzoate 
• 2150-41-6 methyl 2, 4-dimethoxybenzoate 
• 1235865-75-4 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid methyl ester 
• 118737-62-5 2,4-difluorobenzoic acid hydrazide 
• 1356585-72-2 C₁₀H₈F₂N₂O₃S 
• 1092277-16-1 (s)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole-2-thiol 

Relevant articles and documents

Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids

The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.

Hydrogen Bond Directed Photocatalytic Hydrodefluorination and Methods of Use Thereof

Methods of synthesizing compounds comprising fluorinated aryl groups are disclosed, wherein said methods utilize hydrogen bond directed photocatalytic hydrodefluorination.

Room Temperature Carbonylation of (Hetero) Aryl Pentafluorobenzenesulfonates and Triflates using Palladium-Cobalt Bimetallic Catalyst: Dual Role of Cobalt Carbonyl

An efficient method for the carbonylation of (hetero) aryl pentafluorobenzenesulfonates and triflates under exceptionally mild conditions using palladium/dicobalt octacarbonyl [Pd/Co2(CO)8] has been developed. Besides acting as carbon monoxide (CO) source, Co2(CO)8enhances the reaction rate by accelerating the CO insertion through an in situ generated bimetallic palladium cobalt tetracarbonyl [Pd-Co(CO)4] complex. Under the optimized reaction condition, carbonylation of a wide range of activated and deactivated, as well as sterically hindered and heteroaromatic, substrates proceeded efficiently at room temperature. The high chemoselectivity and improved synthesis of biologically relevant Isoguvacine and Lazabemide intermediates highlights its scope as a valuable synthetic method. The generality of this protocol was further extended to other electrophiles (bromides, chlorides and tosylates). (Figure presented.).