106689-40-1Relevant articles and documents
AUTRE VOIE D'ACCES AUX 5H-PYRIDOPYRROLOPYRIDINES ET LEUR TRANSFORMATION EN DERIVES N-5 ET N-8 SUBSTITUES
Hung, Nguyen Chi,Bisagni, Emile
, p. 2303 - 2310 (1986)
4-hydrazino-1H-pyridin-2-ones obtained starting from corresponding 2,4-dihydroxypiridines react with N-acetyl 4-piperidone.The expected hydrazones then give 6,7,8,9-tetrahydro 8-acetyl-2H,5H-pyridopyrrolopyridin-1-ones by thermal Fischer indole reaction.Aromatization of these last compounds with 10 percent palladized charchoal gives 2H,5H-pyridopyrrolopyridin-1-ones providing a new reaction pathway to this series which is more convenient that the one described in the preceding paper.Whereas the alkylation of the N-matallated species derived from 1-chloro-4-methyl-5H-pyridopyrrolopyridine by alkyl halides leads to the mixture of N-5 and N-8 alkyl derivatives, 1-chloro-5H-pyridopyrrolopyridine gives only the N-5 alkylated compound.