106877-33-2

Basic information

• Product Name: 5-Amino-2-(trifluoromethyl)pyridine
• Synonyms: 6-(trifluoromethyl)pyridin-3-amine hydrochloride;5-AMINO-2-(TRIFLUOROMETHYL)PYRIDINE;3-AMINO-6-(TRIFLUOROMETHYL)PYRIDINE;6-Trifluoromethylpyridin-3-amine;5-Amino-2-(trifluoromethyl)pyridine 98%;5-Amino-2-(trifluoromethyl)pyridine98%;6-(trifluoroMethyl)-3-aMinopyridine;6-(TrifluoroMethyl)pyridine-3-aMine
• CAS NO: 106877-33-2
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.11
• EINECS: 1312995-182-4
• Product Categories: Nitrogen cyclic compounds;Amines;blocks;FluoroCompounds;Pyridines;Pyridine Series;Amines and Anilines;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;C6;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Fluorine series
• Mol File: 106877-33-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 39-43 °C(lit.)
• Boiling Point: 92-94/0.01mm
• Flash Point: >230 °F
• Appearance: white to light yellow crystal powder
• Density: 1.368 g/cm³
• Vapor Pressure: 0.0821mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.49±0.22(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Amino-2-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-(trifluoromethyl)pyridine(106877-33-2)
• EPA Substance Registry System: 5-Amino-2-(trifluoromethyl)pyridine(106877-33-2)

Safety Data

• Hazard Codes: T,Xi,C
• Statements: 25-36/38-43-34-22
• Safety Statements: 26-36/37-45-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 106877-33-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 106877-33-2 differently. You can refer to the following data:
1. Employed in a covenient, one-pot, synthesis of azaindoles.1
2. Employed in a convenient, one-pot, synthesis of azaindoles.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)5-2-1-4(10)3-11-5/h1-3H,10H2

Upstream product

• 386715-35-1 6-(trifluoromethyl)pyridine-3-carboxamide 
• 462-08-8 pyridin-3-ylamine 
• 2314-97-8 iodotrifluoromethane 

Downstream Products

• 648423-74-9 Methyl (6-trifluoromethyl-pyridin-3-yl]-carbamate 
• 873107-98-3 5-iodo-2-(trifluoromethyl)pyridine 
• 930283-01-5 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-N-(6-(trifluoromethyl)pyridin-3-yl)-1H-imidazole-4-carboxamide 
• 1159997-20-2 (R)-1-(4-(trifluoromethyl)phenyl)-N-(6-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 1219626-71-7 2-[3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl]-N-[6-(trifluoromethyl)pyridin-3-yl]acetamide 
• 1051372-38-3 3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(4-(trifluoromethyl)pyridin-3-yl)propanamide 
• 1137670-97-3 {5-[2-(2,6-dichloro-phenyl)-3H-benzoimidazol-5-yl]-[1,3,4]oxadiazol-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-amine 
• 927867-41-2 N-[2-Iodo-6-(trifluoromethyl)-3-pyridyl]benzenesulfonamide 
• 820225-10-3 O-ethyl S-(6-(trifluoromethyl)pyridin-3-yl) carbonodithioate 
• 1050499-87-0 N₄-(3-chloro-4-fluorophenyl)-N₂-(6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2,4-diamine 
• 920979-04-0 2-iodo-6-(trifluoromethyl)pyridin-3-amine 
• 1020323-81-2 N-[6-(trifluoromethyl)pyridin-3-yl]-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide 
• 873852-18-7 4-chloro-3-{N-(3-chloropyridin-2-yl)-N-[2-(tetrahydropyran-2-yl)oxyethyl]amino}-N-(2-trifluoromethylpyridin-5-yl)-benzamide 
• 117519-09-2 3-amino-2-chloro-6-(trifluoromethyl)pyridine 

Relevant articles and documents

Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder

A series of novel cyanoguanidine derivatives was designed and synthesized. Condensation of N-(1-benzotriazol-1-yl-2,2-dichloropropyl)-substituted benzamides with N-(substituted-pyridin-3-yl)-N′-cyanoguanidines furnished N-{2,2-dichloro-1-[N′-(substituted-pyridin-3-yl)-N′-cyanoguanidino] propyl}-substituted benzamide derivatives. These agents were glyburide-reversible potassium channel openers and hyperpolarized human bladder cells as assessed by the FLIPR membrane potential dye (KATP-FMP). These compounds were also potent full agonists in relaxing electrically stimulated pig bladder strips, an in vitro model of overactive bladder. The most active compound 9 was evaluated for in vivo efficacy and selectivity in a pig model of bladder instability. Preliminary pharmacokinetic studies in dog demonstrated excellent oral bioavailability and a t1/2 of 15 h. The synthesis, SAR studies, and biological properties of these agents are discussed.

Experimental and Computational Studies of Trifluoromethylation of Aromatic Amines by the System Trifluoroiodomethane-Zinc-Sulfur Dioxide

Several trifluoromethyl-substituted aromatic and heteroaromatic amines have been obtained by the reactions of the corresponding amines with the title reagent system.Computational results provide rationalization for the observed regioselectivities and support a mechanism in which the electrophilic trifluoromethyl radicals interact with the aromatic ring at the sites with the greatest electron density of the HOMO orbitals, and then the resultant adducts are oxidized to cations.The products obtained are potential building blocks for a number of heterocyclic systems.