106916-72-7Relevant articles and documents
Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation
Sehajpal, Shikha,Prasad, Deo Nandan,Singh, Rajesh K.
, (2019)
Ketoprofen belongs to one of the most common nonsteroidal anti-inflammatory drugs (NSAIDs) but its clinical usefulness has been restricted due to the high incidence of gastrointestinal complications. The release of reactive oxygen species (ROS) in NSAIDs
Solvent- and base-free dicyclohexylcarbodiimide-promoted esterifications
Streinz,Koutek,?aman
, p. 809 - 811 (2001)
N,N'-Dicyclohexylcarbodiimide/base-promoted esterification of carboxylic acids containing α-halogen atom(s) gave low yields of products when performed in a solvent. This failure was found to be due to the low stability of appropriate intermediates under t
Synthesis, characterization and applications of some novel DMAP-based chiral ionic liquids
Singh, Avtar,Chopra, Harish Kumar
, p. 106 - 111 (2018)
A convenient and efficient procedure for the synthesis of some novel chiral ionic liquids (CILs) from 4-dimethylaminopyridinium cation has been reported. The synthesis of the CILs includes the treatment of optically active (?)-menthyl ester with 4-dimethy
SYNTHESIS AND STRUCTURE OF AMINO ESTERS OF MENTHOL
Raikova, T. S.,Kalechits, G. V.,Manukov, E. N.,Vyalimyae, T. K.,Makhach, S. A.
, p. 526 - 529 (1981)
The conditions for the acylation of (-)-menthol with monochloroacetyl chloride have been studied.Amino esters of (-)-menthol have been obtained by the nuclephilic replacement of the chlorine in (-)-menthol monochloroacetate by residues of secondary amines
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Sisido,K. et al.
, p. 4878 - 4881 (1961)
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Stereoselective oxidation of methyl phenyl sulfide in the presence of chiral ionic liquids
Akopyan,Rakhmanov,Grigor'Ev,Ryzhov,Tarakanova,Anisimov
, p. 1302 - 1307 (2014)
Several ionic liquids containing a chiral center either in the cation or in the anion have been prepared. They have been applied as catalysts and solvents for stereoselective oxidation of methyl phenyl sulfide to obtain the respective sulfoxide.
Catalytic Sc(OTf)3 mediated direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate with aldehydes by using (?)-menthol as chiral auxiliary
Bhangare, Dattatraya N.,Shinde, Rohit G.,Pawar, Pushpalata D.,Nikalje, Milind D.,Lokhande, Mahendra N.
supporting information, p. 1878 - 1882 (2021/05/27)
This method involves the direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate 5 with a variety of substituted aromatic aldehydes, which offers a convenient method for the synthesis of intermediate containing biologically relevant α-amino
Novel N-4-Piperazinyl Ciprofloxacin-Ester Hybrids: Synthesis, Biological Evaluation, and Molecular Docking Studies
Mahdavi, M.,Mostafavi, H.,Shahbazi, A.,Zarrini, G.
, p. 1558 - 1565 (2020/09/21)
Abstract: A series of novel N-4-piperazinylciprofloxacin-ester hybrids has been synthesized and the structures confirmed by1H and 13C NMR, FT-IRspectral data, and elemental analysis. The products have been tested in vitro for their antibacterial activity againstsix bacterial strains (MRSA, Staphylococcusepidermidis, Bacillussubtilis, Escherichia coli,Salmonella enterica, and Klebsiella pneumoniae) and have demonstrated goodantibacterial activity with MIC values range 6.25–200 μg/mL. Antifungal andcytotoxic activities of the products have been tested against Candida kefyr and human leukemia K562 cell line,respectively. All compounds inhibit growth of K562 cells more efficiently thanthe parent ciprofoxacin in a dose- and duration-dependent way. Molecular dockingstudies performed for the compound 3i indicatesthat similarly to ciprofloxacin it can act as an inhibitor of S. aureus DNA gyrase.
