106983-30-6 Usage
Description
N-OCTANOYL-DL-HOMOSERINE LACTONE is a synthetic compound that belongs to the class of homoserine lactones, which are known for their role as signaling molecules in various biological processes. It is characterized by an octanoyl chain attached to a homoserine lactone backbone, which contributes to its unique properties and applications.
Uses
Used in Application Test:
N-OCTANOYL-DL-HOMOSERINE LACTONE is used as an inducer for violacein expression in Chromobacterium violaceum mutants that are typically unable to produce homoserine lactones. This application is significant in the study of bacterial communication and the role of homoserine lactones in regulating gene expression and other cellular processes.
Biochem/physiol Actions
N-Octanoyl-DL-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella are involved in quorum sensing, cell to cell communication among bacteria. Some AHLs are potent chemoattractants for human immune cells such as neutrophils.
Check Digit Verification of cas no
The CAS Registry Mumber 106983-30-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,9,8 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 106983-30:
(8*1)+(7*0)+(6*6)+(5*9)+(4*8)+(3*3)+(2*3)+(1*0)=136
136 % 10 = 6
So 106983-30-6 is a valid CAS Registry Number.
106983-30-6Relevant articles and documents
Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators
Sabbah, Mohamad,Fontaine, Fanny,Grand, Lucie,Boukraa, Mohamed,Efrit, Mohamed L.,Doutheau, Alain,Soulere, Laurent,Queneau, Yves
scheme or table, p. 4727 - 4736 (2012/08/29)
New analogues of N-acyl-homoserine-lactone (AHL), in which the amide was replaced by a triazole or tetrazole ring, were prepared and tested for their activity as LuxR-dependent QS modulators. Several compounds showed a level of antagonistic or agonistic activity, notably some 1,4-triazolic and 1,5-tetrazolic derivatives, whereas the 2,5-tetrazolic compounds were inactive. In 1,5-tetrazoles, substituted with butyrolactone and an alkyl chain, the activity was reversed, depending on the connection between the lactone and the tetrazole. The C-N connected compounds were agonists whereas the C-C connected ones were antagonists.
