107018-38-2Relevant articles and documents
A simple procedure for nucleophilic perfluoroalkylation of organic and inorganic substrates
Petrov, Viacheslav A.
, p. 3267 - 3269 (2001)
The mixture RfI and tetrakis(dimethylamino)ethylene is used for the nucleophilic perfluoroalkylation. The reaction of chlorotrimethylsilane and RfI/tetrakis(dimethylamino)ethylene in diglyme results in the formation of RfSi(CH3)3 isolated in 55-81% yield. The interaction of this system with organic electrophiles such as benzoyl and benzensulphonyl chlorides, aliphatic and aromatic aldehydes and activated ketones leads to the formation of the corresponding condensation products in 24-62% yield.
A chiral triaminosulfonium salt: Design and application to catalytic asymmetric synthesis
Kuroki, Yoshichika,Iseki, Katsuhiko
, p. 8231 - 8234 (1999)
The first chiral triaminosulfonium salt, tris((S,S)-3,4-diphenylpyrrolidino)sulfonium difluorotriphenylstannate, catalyzes trifluoromethylation of benzaldehyde with (trifluoromethyl)trimethylsilane to give the corresponding optically active alcohol with 52% ee.
Fluoroform: An efficient precursor for the trifluoromethylation of aldehydes
Folleas, Benoit,Marek, Ilan,Normant, Jean-F,Jalmes, Laurent Saint
, p. 2973 - 2976 (1998)
Fluoroform is shown to be an efficient trifluoromethylating agent when deprotonated using standard reagents in DMF. The important role of DMF in that reaction was demonstrated.
Organocatalysis approach to trifluoromethylation with fluoroform
Zhang, Yuan,Fujiu, Motohiro,Serizawa, Hiroki,Mikami, Koichi
, p. 367 - 371 (2013)
The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently.
BIARYL PYRAZOLES AS NRF2 REGULATORS
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Page/Page column 425; 426, (2017/08/01)
The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
Polyfluoroalkylation of carbonyl compounds by polyfluoroalkyl anions generated from polyfluorocarboxamides
Wakita, Natshumi,Hara, Shoji
, p. 1201 - 1212 (2016/11/07)
Polyfluoroalkyl anions, generated by reduction of (polyfluoroalkanoyl)piperidines with Et3BHK, were used for the polyfluoroalkylation of carbonyl compounds. Trifluoromethylation of aromatic aldehydes proceeded in good yields, and that of aliphatic aldehydes afforded a moderate yield. In contrast, the yield was low when the reaction involved benzophenone. Pentafluoroethylation and octafluorobutylation of aldehydes were also carried out by using the corresponding (polyfluoroalkanoyl)piperidines, which were prepared from commercially available polyfluorocompounds. The (polyfluoroalkanoyl)piperidines were also prepared through polyfluorination, and were used in the polyfluoroalkylation of aldehydes.
