1071495-68-5

Basic information

• Product Name: {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]quinolin-5-yloxy}acetic acid
• Synonyms: {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]quinolin-5-yloxy}acetic acid
• CAS NO: 1071495-68-5
• Molecular Weight: 513.516
• Mol File: 1071495-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]quinolin-5-yloxy}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]quinolin-5-yloxy}acetic acid(1071495-68-5)
• EPA Substance Registry System: {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]quinolin-5-yloxy}acetic acid(1071495-68-5)

Safety Data

• Hazardous Substances Data: 1071495-68-5(Hazardous Substances Data)

Upstream product

• 844501-71-9 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 1068159-14-7 [3-(4-bromobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid methyl ester 

Relevant articles and documents

QUINOLINES AND THEIR THERAPEUTIC USE

Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently -OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms; R5 is hydrogen or halogen; R6 is C1C6alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms; X is -CH2-, -S-, or -O-; one of Y and Y1 is hydrogen and the other is OR6, -C(=O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the specification; and R6, R7 and R8 are as defined in the specification.