107389-91-3

Basic information

• Product Name: Cleroindicin B
• Synonyms: Cleroindicin B;4-Hydroxy-4-(2-hydroxyethyl)cyclohexanone
• CAS NO: 107389-91-3
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.19496
• Mol File: 107389-91-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312.1 °C at 760 mmHg
• Flash Point: 156.8 °C
• Appearance: /
• Density: 1.185 g/cm³
• Vapor Pressure: 4.77E-05mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: Cleroindicin B(CAS DataBase Reference)
• NIST Chemistry Reference: Cleroindicin B(107389-91-3)
• EPA Substance Registry System: Cleroindicin B(107389-91-3)

Safety Data

• Hazardous Substances Data: 107389-91-3(Hazardous Substances Data)

Usage

General Description

Cleroindicin B is a natural product isolated from the marine-derived fungus Aspergillus clavatus. It belongs to the class of compounds known as indoledioxopiperazines and displays potent anticancer activity against a wide range of cancer cell lines. Cleroindicin B inhibits the growth of cancer cells by inducing apoptosis, or programmed cell death, and also shows antimicrobial and anti-inflammatory properties. Cleroindicin B has the potential to be developed as a therapeutic agent for the treatment of cancer and other diseases. Its unique structure and bioactivity make it an interesting target for further research in the field of drug discovery and development.

InChI:InChI=1/C8H14O3/c9-6-5-8(11)3-1-7(10)2-4-8/h9,11H,1-6H2

Upstream product

• 501-94-0 p-hydroxyphenethyl alcohol 
• 28251-63-0 tetraacetyl salidroside 
• 214678-27-0 ((1R,4S,4aR,5S,8R,8aS)-8-Acetoxy-5-hydroxy-1,4,4a,5,8,8a-hexahydro-1,4-methano-naphthalen-5-yl)-acetic acid ethyl ester 
• 189509-22-6 (8-hydroxy-1,4-dioxaspiro[4,5]dec-8-yl)-acetic acid ethyl ester 
• 678967-25-4 3-(1-Phenyl-vinyl)-1,2,5-trioxaspiro[5.5]undec-9-one 
• 872891-55-9 9-(2-hydroxy-ethyl)-3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecan-9-ol 
• 189509-23-7 8-(2-hydroxyethyl)-1,4-dioxaspiro[4,5]decan-8-ol 
• 93675-95-7 rengyoxide diacetate 
• 123563-44-0 rengyoside B 
• 10338-51-9 Salidroside 
• 40661-45-8 cornoside 
• 214678-47-4 Acetic acid (1R,4R)-1-(2-acetoxy-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl ester 
• 214678-36-1 ((1R,4S,4aR,5S,8aS)-5-Hydroxy-8-oxo-1,4,4a,5,8,8a-hexahydro-1,4-methano-naphthalen-5-yl)-acetic acid ethyl ester 
• 214678-40-7 (1R,4S,4aR,5R,8R,8aS)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(2-hydroxy-ethyl)-1,4,4a,5,6,7,8,8a-octahydro-1,4-methano-naphthalen-5-ol 

Downstream Products

• 123563-44-0 rengyoside B 
• 101489-38-7 trans-1-(2-hydroxyethyl)cyclohexane-1,4-diol 
• 93675-85-5 cis-1-(2-hydroxyethyl)cyclohexane-1,4-diol 
• 189577-41-1 2-phenyl-1,3-dioxa-spiro[5.5]undecan-9-ol 
• 189509-26-0 2-phenyl-1,3-dioxa-spiro[5.5]undecan-9-ol 
• 189577-42-2 acetic acid 2-phenyl-1,3-dioxa-spiro[5.5]undec-9-yl ester 
• 189509-27-1 acetic acid 2-phenyl-1,3-dioxa-spiro[5.5]undec-9-yl ester 
• 189509-25-9 2-phenyl-1,3-dioxa-spiro[5.5]undecan-9-one 
• 93675-96-8 rengyoxide dimethyl ketal 

Relevant articles and documents

Protection of the carbonyl group as 1,2,4-trioxane and its regeneration under basic conditions

(Chemical Equation Presented) An experimental protocol demonstrating the protection of the carbonyl group as 1,2,4-trioxane, the stability of the protecting group under a variety of reaction conditions, and the regeneration of the carbonyl group with Triton B in THF at room temperature is presented. The method provides a useful alternative for the protection of carbonyl compounds having acid-sensitive moieties.

Chemoenzymatic synthesis of rengyoside-A, -B, isorengyoside and synthesis of their aglycones

The chemoenzymatic synthesis of a group of naturally occurring cyclohexylethanoids, rengyoside-A, -B and isorengyoside, has been performed by enzymatic glucosidation of their chemically synthesized aglycones, rengyol, rengyoxide and isorengyol.

STRUCTURES OF RENGYOSIDES A, B AND C, THREE GLUCOSIDES OF FORSYTHIA SUSPENSA FRUITS

Three new glucosides, rengyosides A, B and C, having as aglycones the reduced forms of phenylethanol, were isolated from Forsythia suspensa fruits.Chemical and spectroscopic studies established the structures of these natural products to be 2-(1,4-dihydroxycyclohexyl)ethyl β-D-glucopyranoside, 2-(1-hydroxy-4-ketocyclohexyl)ethyl β-D-glucopyranoside and 2-(1,4-dihydroxycyclohexyl)ethyl β-D-6-O-glucopyranoside, respectively.Saliroside, a possible biogenetic precursor of these glucosides, was also isolated. Key Word Index- Forsythia suspensa; Oleaceae; rengyoside A; rengyoside B; rengyoside C; cyclohexylethyl glucosides.