1074-16-4

Basic information

• Product Name: 2-BROMOPHENETHYLALCOHOL
• Synonyms: 2-BROMOPHENYLETHANOL;2-BROMOPHENETHYLALCOHOL;2-(2-BROMOPHENYL)ETHANOL;Benzeneethanol, 2-bromo-;2-BROMOPHENETHYLALCOHOL 99%;2-(2-Bromophenyl)ethyl Alcohol;2-Bromophenethylalcohol,99%;2-bromophenethyl alcohol or 2-(2-bromophenyl)ethyl alcohol
• CAS NO: 1074-16-4
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.06
• Product Categories: blocks;Bromides;Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 1074-16-4.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 97 °C0.7 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear slightly yellow/Liquid
• Density: 1.483 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0036mmHg at 25°C
• Refractive Index: n20/D 1.577(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO, Ethyl Acetate
• PKA: 14.70±0.10(Predicted)
• CAS DataBase Reference: 2-BROMOPHENETHYLALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOPHENETHYLALCOHOL(1074-16-4)
• EPA Substance Registry System: 2-BROMOPHENETHYLALCOHOL(1074-16-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 1074-16-4(Hazardous Substances Data)

Usage

Chemical Properties

clear slightly yellow liquid

Uses

Different sources of media describe the Uses of 1074-16-4 differently. You can refer to the following data:
1. 2-Bromophenethyl alcohol is a brominated phenethanol derivative used as a building block in the preparation or bicyclic and tricyclic heterocycles.
2. 2-Bromophenethyl alcohol is used as an end capping reagent during the synthesis of rod-coil block copolymers and also as a test compound in the study to evaluate the potential Aedes aegypti repellent chemotype.

General Description

2-Bromophenethyl alcohol is a phenethyl alcohol derivative. It participates in the preparation of novel P-chirogenic phosphines with a sulfur-chelating arm (P*,S-hybrid ligand).

InChI:InChI=1/C8H9BrO/c9-8-4-2-1-3-7(8)5-6-10/h1-4,10H,5-6H2

Upstream product

• 951386-58-6 1-(2-(allyloxy)ethyl)-2-bromobenzene 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 130089-19-9 1-bromo-2-(2-methoxyethenyl)benzene 
• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 
• 13292-87-0 dimethylsulfide borane complex 
• 18698-97-0 ortho-bromophenylacetic acid 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 96557-30-1 2-bromophenylacetaldehyde 
• 60-12-8 2-phenylethanol 
• 2039-88-5 2-bromostyrene 

Downstream Products

• 229184-03-6 5-benzyloxy-1-[2-(2-bromo-phenyl)-ethyl]-3-(4-methyl-thiazol-2-yl)-1H-pyridin-2-one 
• 75534-18-8 1-bromo-2-(2-chloro-ethyl)benzene 
• 1961-97-3 3-phenyl-1H-indene 
• 30516-40-6 3-phenyl-2,3-dihydro-1H-inden-1-ol 
• 496-16-2 2.3-dihydrobenzofuran 
• 1000014-28-7 2-(2-bromophenyl)-1-triisopropylsilyloxyethane 
• 666726-89-2 4-{1-[2-(2-bromophenyl)ethoxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl estert 
• 1201847-11-1 C₂₂H₂₁BrO 
• 1122567-80-9 2-(2-bromophenyl)ethyl carbamate 
• 61698-07-5 3-(2-bromo-phenyl)-propionitrile 
• 1103533-46-5 S-2-bromophenethyl ethanethioate 
• 473528-52-8 2-(2-thienyl)phenethyl alcohol 
• 2178-20-3 2-<2-Phenylmercapto-aethyl>-benzoesaeure 

Relevant articles and documents

Cascade intramolecular Prins/Friedel–Crafts cyclization for the synthesis of 4-aryltetralin-2-ols and 5-aryltetrahydro-5H-benzo[7]annulen-7-ols

The treatment of 2-(2-vinylphenyl)acetaldehydes or 3-(2-vinylphenyl)propanals with BF3·Et2O results in an intramolecular Prins reaction affording intermediary benzyl carbenium ions, which are then trapped by a variety of electron-ric

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of which entails the activation of a SUMO protein through an ATP-dependent process catalyzed by SUMO-activating enzyme (SAE). Here, we describe the identification of TAK-981, a mechanism-based inhibitor of SAE which forms a SUMO-TAK-981 adduct as the inhibitory species within the enzyme catalytic site. Optimization of selectivity against related enzymes as well as enhancement of mean residence time of the adduct were critical to the identification of compounds with potent cellular pathway inhibition and ultimately a prolonged pharmacodynamic effect and efficacy in preclinical tumor models, culminating in the identification of the clinical molecule TAK-981.

Reliably Regioselective Dialkyl Ether Cleavage with Mixed Boron Trihalides

A protocol for the regioselective cleavage of unsymmetrical alkyl ethers to generate alkyl alcohol and alkyl bromide products is described. A mixture of trihaloboranes triggers this conversion and exhibits improved reactivity profiles (regioselectivity and yield) compared with BBr3 alone. Additionally, this procedure allows the efficient synthesis of (B-Cl) dialkyl boronate esters. There are limited methods to generate acyclic dialkoxyboryl chlorides, and these intermediates constitute important synthons in main-group chemistry.