1074-76-6

Basic information

• Product Name: 2,4-Dimethyl-3-nitropyridine
• Synonyms: 2,4-DIMETHYL-3-NITROPYRIDINE;3-Nitro-2,4-dimethylpyridine;2,4-dimethyl-3-nitropyridine(SALTDATA: FREE);4-Methyl-pyriMido[1,2-b]pyridazin-2-one;2,4-DiMethyl-3-nitropyridine, 97%, 97%;Pyridine, 2,4-dimethyl-3-nitro-
• CAS NO: 1074-76-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Product Categories: Heterocycles;Heterocyclic Compound;Pyridines
• Mol File: 1074-76-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 9.5 °C
• Boiling Point: 233.601 °C at 760 mmHg
• Flash Point: 95.079 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 2.57±0.18(Predicted)
• CAS DataBase Reference: 2,4-Dimethyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-3-nitropyridine(1074-76-6)
• EPA Substance Registry System: 2,4-Dimethyl-3-nitropyridine(1074-76-6)

Safety Data

• Hazardous Substances Data: 1074-76-6(Hazardous Substances Data)

Usage

General Description

2,4-Dimethyl-3-nitropyridine is a chemical compound that belongs to the class of organic compounds known as pyridines and derivatives. Pyridines are compounds containing a pyridine ring, which is a six-membered aromatic ring with one nitrogen atom. As a nitropyridine, it contains a nitro group (-NO2) attached to the pyridine ring. This chemical is used mainly in the field of organic synthesis. It is soluble in common organic solvents, is light yellow in color, has a strong odorous smell, and is prone to violent reactions if mixed with strong reducing substances. It must be handled carefully due to its potential risks and hazards in both its usage and disposal.

InChI:InChI=1/C7H8N2O2/c1-5-3-4-8-6(2)7(5)9(10)11/h3-4H,1-2H3

Upstream product

• 21203-62-3 4,6-dimethyl-5-nitro-pyridine-2-carboxylic acid 
• 108-47-4 2,4-lutidine 
• 23056-45-3 2-bromo-3-nitro-4-methyl pyridine 
• 583-61-9 2,3-Lutidine 

Downstream Products

• 1427502-61-1 1-(7-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)ethanone 
• 1612241-91-4 4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide 
• 1612242-58-6 C₂₄H₁₉F₄N₇O₅S 
• 1612242-38-2 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide 
• 1193-71-1 5-amino-2,4-dimethylpyridine 
• 108-47-4 2,4-lutidine 
• 480-98-8 7-methyl-1H-pyrrolo[2,3-c]pyridine 
• 143509-33-5 2,4-dimethyl-3-hydroxypyridine N-oxide 
• 143509-47-1 3-hydroxy-4-methylpyridine-2-carboxaldehyde 
• 27296-76-0 2,4-dimethyl-pyridin-3-ol 
• 21203-74-7 4-methyl-3-nitropyridine-2-carboxaldehyde 
• 1073-21-8 3-amino-2,4-dimethylpyridine 

Relevant articles and documents

Kras-G12C inhibitor heterocyclic compounds

The invention relates to Kras-G12C inhibitor heterocyclic compounds and a preparation method thereof, and application of the compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds provided by the invention are obtained through a series of reactions such as a condensation reaction, an intramolecular cyclization reaction, a chlorination reaction, an SN2 reaction, a coupling reaction, deprotection and the like.

COMPOUNDS HAVING BOTH α7 NICOTINIC AGONIST ACTIVITY AND 5HT3 ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES

The invention discloses compounds that are selective α7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases.

The synthesis of β-nitropyridine compounds

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitro-pyridine 36%, 3-methyl-5-nitropyridinc 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, methyl 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%.